肺癌纵膈淋巴结转移与血行转移相关性的临床研究.pdfVIP

164 肺癌 2004 年 3 月 25 日第 24 卷第 2 期 Tumor Mar. 2004 , Vol. 24 , No. 2 临床研究 肺癌纵脯淋巴结转移与血行转移相关性的临床研究 王洲婚刘相燕刘凡英张林陈景寒 摘要:目的 探讨非小细胞肺癌 CNSCLC) 纵隔淋巴结转移 CN， )与血行转移的相关性，为对手术后的 N，肺癌采取有针对性的 辅助治疗措施提供依据。方法 对 96 例根治性切除术后病理诊断为纵隔淋巴结转移 (pN，)的 NSCLC 患者进行回顾性研究， 选择元淋巴结转移 CpNo ) 的 NSCLC 患者作为对照组，与 pN2 患者配对。术后两年内每 6 个月对患者进行随访复查一次，监测 血行转移。计算两组患者血行转移的发生率，应?? t 检验比较发生率的差别。结果 pN，组患者手术后两年内血行转移的 发生率为 29.17%. 多数为脑和肺转移 (64.29%) ;pNo 组患者血行转移的发生率为 13.54% .两者的差别非常显著 (PO.Ol) 。 pN，肺癌患者术后发生血行转移的概率大约是 pNo 患者的 3 倍 COR=3.14) 。结论 肺癌根治切除术后血行转移的发生与纵 隔淋巴结转移有关，有纵隔淋巴结转移的患者血行转移的发生率增高。 关键词:肺肿瘤; 癌，非小细胞肺; 肿瘤转移; 纵痛淋巴结转移; 血行转移 中图分类号 :R734.2 文献标识码 :A 文章编号: 1000-7431 (2004)02-0164-03 Clinical study of correlation between mediastinal Iymph node metastasis with blood-borne metastasis in patients with non-small celllung cancer WANG Zhou. LIU Xiangyan. LIU Fanying. ZHANG Ling. CHEN ] inghan. (Deρartment of Thoracic Surgery. Shandong Provincial Hos纠 tal. Clinical College of Shandong University ] inan 250021. China) Abstract: Objective To investigate the correlation between mediastinallymph node metastasis and blood-borne metastasis in pa? tients with non-small celllung cancer (NSCLC). Methods Clinical data of 96 patients with NSCLC. who underwent radical sur? gery and were diagnosed to be with mediastinallymph node metastasis (pN,) determined by histopathologic examination. were reviewed. Ninety-six patients without lymph node metastasis (pNo ) were matched into pairs with the patients with pN, disease. Postoperative pat