肾癌伴单发转移灶的治疗方法探讨.pdfVIP

990 Clinical Medical Journal of China , 2006. Vol. 13 , No. 6 φ1勤 l 降 2年穰箩 2006 年 12 月第 13 卷第 6 期 ·论著· 肾癌伴单发转移灶的治疗方法探讨 林宗明张建平孙立安张立朱闷玉郭剑明许明张永康玉国民 摘要 阔的 2 探讨肾细胞癌 #J在发转移灶病例的治疗方法。方法:回顾性分析 1986-2003 年肾癌伴学发转移和肾癌根治 术后复发且在个转移共 51 例病人的临床资料。除 2 例脑转移行放疗外， 49 例均行转移灶的外科切除辅以千扰索治疗。结 果， 17 例肾痕根治及转移灶切除(1仔1 放疗)治疗，总的平均生存期 26.3 个月。 34 例复发单个转移灶手术切除(1例放疗) 后，总的平均生将期为 4 1. 9 个月。肾癌根治切除术后复发转移问期在 1 年内的，转移灶切除后平均生存 30.5 个月，超过 1 年复发转移的为 6 1. 8 个月 (P0.05) 。肝和脑转移灶术后疗效较其他~位的转移灶预后差。结论:对肾娘伴单发转移 和根治术后1.发且在个转移应行肾痕J.t转移:战的外科切除.可延长生存期;1年以上复发转移问期的疗效较好。 关键词 肾癌: 转移; 手术治疗 中图分类粤 R737.11 )c 献标识码 A ExploriJ电脑n咿ment of Renal Cell Carci跚跚呐th Solitary Me刷刷is LIN Zongming ZHANG ] ianρing SUN Lian , et al. De问 rtment of 阶ology ， Zhongshan Hosρ ital ， Fudan University , Shanghai 200032 Abstract Objective: To explore the effect of su咄咄 excí sion for renal cell carcinorna with solitary metastasis. Metbods: Be~ tween 1986-2003, fifty one patients with solitary metastasis to different sites from renal cell carcinom且 or after radical ne? phrectomy for the prirnary le日 ion recurring solitary metastasis were analyzed. Except 2 brain metastasis treated with radiothera? py , other 49 cases underwent surgical excision with interferon more treatment used. ω u1 ts: Patients had solitary metastasis at the time of presentation overall median survival was 26. 3 months. 丁he survival of those who developed solitary metastases during follow- up after nephrectomy for prirnary was 41. 9 months. 丁he patients with longer one year interval between diagnosis and development of metastasis survived 61. 8 months. The sites of metastasis in liver and brain had poor p