TMP of diabetic nephropathy tubulointerstitial lesions and transforming growth factor-β 1 in.docVIP

 PAGE \* MERGEFORMAT 13 TMP of diabetic nephropathy tubulointerstitial lesions and transforming growth factor-β 1 in [Abstract] Objective To observe the TMP (TMP) in diabetic nephropathy (DN) rats with tubulointerstitial lesions and transforming growth factor-β 1 (TGF-β 1) expression level of impact. Methods SD rats were uninephrectomized streptozotocin (STZ)-induced animal model of diabetic nephropathy. Rats were randomly divided into five groups of 12 rats, respectively, as a model group, normal operation group, benazepril (Lotensin) group, TMP high-and low-dose group. In addition to the blank group and model group, the rest of the group divided into four groups according to the benazepril 1.7 mg / (kg * d), TMP 150,50 mg / (kg * d) given orally for 12 weeks. Experiment No. 4 weeks, 8 weeks and 12 weeks to measure urine protein excretion (UAER); treatment of 12 weeks, rats were determined in serum FPG, BUN, Scr, immunohistochemical detection of tubulointerstitial expression of TGF-β 1 . Results In the model rats UAER progressively increased, FPG, BUN, Scr was significantly higher (P amp;lt;0.01; P amp;lt;0.05), tubulointerstitial expression of TGF-β 1 significantly increased (P amp;lt;0.01). TMP high-dose rats UAER decreased, FPG, BUN, Scr decreased tubulointerstitial expression of TGF-β 1 significantly decreased compared with the model group were significantly different (P amp;lt;0.05). Conclusion TMP can down DN rat tubulointerstitial TGF-β 1 expression, tubulointerstitial damage mitigation to achieve the right protective effect of renal function in DN. [Keywords:] TMP Diabetic nephropathy Transforming growth factor-β 1 pathology Diabetic nephropathy (DN) is one of the main end-stage renal failure. DN occurring mechanism is currently not very clear, involves a series of molecular events and histological changes, particularly a variety of cytokines through different channels, different mechanisms play an important role. These cytokines via paracrine and