TNF308 polymorphism and environmental factors in the interaction of hepatocellular carcinoma.docVIP

 PAGE \* MERGEFORMAT 21 TNF308 polymorphism and environmental factors in the interaction of hepatocellular carcinoma Study: Shao-Fang Song, Gao Yan Hui, Chen Sidong [Abstract] Objective To investigate the tumor necrosis factor (TNF) @ 308 polymorphism and environmental factors in the interaction of hepatocellular carcinoma. Methods 1:1 matched case control study, 81 patients in Guangdong Shunde original made for risk factors of hepatocellular carcinoma. by ELISA detection of HBV infection in five indicators, hepatitis C antibody, AFP, liver fluke antibodies, PCR RELP analysis of TNF @ 308 sites. Applied Logistic Regression Model for selected conditions, HCC environmental and genetic risk factors. According to the interaction index to determine the interaction of genes and environment. Results HBsAg, liver disease history, alcohol consumption, TNF2 allele is a risk of liver cancer in Shunde, Guangdong residents factors. HBsAg interacted with the TNF2 allele : OR = 19.83 (95% CI: 4.20 ~ 93.61), the relative risk ratio over (RERI, due to interaction ratio (API, two-factor interaction index (SI 14.39,0.73,4.23, respectively. TNF2 History of liver disease the interactions of alleles: OR = 7.63 (95% CI: 1.05 ~ 67.71), the RERI, API, SI 2.22,0.29,1.50 respectively. there is interaction between alcohol consumption and TNF2 allele: OR = was 4.57 (95% CI: 1.62 ~ 12.88), the RERI, API, SI 1.39,0.30,1.63 respectively. Conclusions The occurrence of liver cancer and genetic risk factors in the environment the result, TNF2 allele is associated with HBsAg, drinking wine, history of liver disease in liver cancer in certain interactions. [Keywords:] @ HCC tumor necrosis factor gene polymorphism interactions Abstract: Objective To study the interaction of the environmental risk factors and the genetic polymorphisms of the human tumor necrosis factor @ 308 position in primary liver cancer (PLC). Methods A case control study was conducted in Shunde, Guangdong. Epidemiol