Tributyltin chloride on mammalian reproductive toxicity and mechanism of.docVIP

 PAGE \* MERGEFORMAT 16 Tributyltin chloride on mammalian reproductive toxicity and mechanism of TBT (tributyltin, TBT) have been primarily as a ship widely used anti-fouling paints, TBT was found to have serious hazard to marine life, particularly sexual distortion caused by molluscs, leading to degradation, population numbers have drastically declined 〔 1〕 , in 2003, banned . Because of its long-term residual, even after a long period of inactivity, sea water and sediment remain TBT, and then accumulate in marine organisms, their enrichment factor between about 5000 to 25000, and after cooking will still be there after the , suggesting that consumption of seafood, there may be potential hazards of TBT 〔 2〕 . Tributyltin chloride (tributyltin chloride, TBTC) is the TBT in the water main forms. Therefore this paper TBTC on mammalian reproductive toxicity and its mechanism of research are reviewed. 1 TBTC on mammalian reproductive toxicity studies have shown that many chemicals in the environment have a role in interfering with the endocrine system, these compounds are called endocrine disruptors, TBT is one of them. These substances affect the biological reproductive function, interference with hormone secretion in vivo, resulting in reproductive and genetic consequences. TBTC mammalian reproductive toxicity studies more focused on the impact of male animals and its mechanisms, and for females is to study the impact of multiple embryos resulting from toxic exposure during pregnancy. 1  1 embryo toxicity pregnancy at different times with different doses of TBTC exposure of pregnant rats may lead to different results. A certain dose of TBTC exposure during early pregnancy in the rat caused by infertility. Harazono 〔 3,4〕 so as to 0,8  1,12  2,16  3mg/kg TBTC the first 0 ~ 7d of pregnancy in rats exposed to gavage, at 20d of gestation were sacrificed to observe the pregnancy outcomes. Found that 12  2 and 16  3mg/kg TBTC dose group did not implant