Tumor necrosis factor α (TNF α) role in liver regeneration_0.docVIP

 PAGE \* MERGEFORMAT 19 Tumor necrosis factor α (TNF α) role in liver regeneration Of: Zhang Xiao Zhang Fang Wang Yan Li Rongcheng can Chau [Abstract] the liver has great regenerative capacity, a variety of cytokines and growth factors involved in the regulation of liver regeneration. Including tumor necrosis factor-@ (TNF @) in the regeneration both play an indispensable role. In this paper, TNF @ at the start of liver regeneration, and promote or inhibit liver cell apoptosis mechanism reviewed in the paper. [Keywords:] tumor necrosis factor-@ (TNF @); liver regeneration The liver is the most important human and animal organs of the body, are responsible for at least more than five thousand kinds of physiological functions [1]. Under normal circumstances, only 0.0012% of liver cells to 0.01% of the liver cell mitosis, but liver injury (surgical excision, chemical, physical or viral injury) will show a strong ability to regenerate [2]. Experiments show that the continuous removal of part of the residual liver lobe of rats to make use of compensatory proliferation of hepatocytes rapid proliferation, so that 2 / 3 hepatectomy can be about 1 week to restore the original liver weight and function, restoring the regeneration of liver cells will stop [3-6]. to stop by the precision of control, when the liver regeneration reached its weight and a certain percentage of the weight, the liver regeneration automatically stopped [7]. Liver regeneration is a variety of signaling factors involved, such as cyclins, inhibitors, cytokines, stimulating factor, oncogene, cell-cell, cell matrix interactions and the precise and orderly regulation of complex processes. It starts with required to terminate the participation of cytokines, some positive regulation of cytokines (HGF, EGF, TGF @, etc.) and negative regulation of cell factor (TGF β, etc.) interact together to complete. However, due to the complexity of liver regeneration, many of the detailed mechanisms nee