Turbidimetry automatic measurement Acetylspiramycin potency tablets.docVIP

 PAGE \* MERGEFORMAT 13 Turbidimetry automatic measurement Acetylspiramycin potency tablets [Abstract] Objective To establish a Turbidimetric Determination of Acetylspiramycin film method. Method of experimental Staphylococcus aureus bacteria, fungi increases about 0.5% (V / V), (37 ± 0.5) ℃ culture 3.5 ~ 4.5h determination. The results of the linear concentration of antibiotic 3.2 ~ 15.6μ g/ml, the average recovery was 100.7% (n = 9), RSD = 1.4%. Conclusion This method is convenient, rapid, sensitive and low confidence limits, accurate and precision is good, can be used as Acetylspiramycin Tablets titer determination. [Keywords:] value; turbidimetry; Acetylspiramycin ABSTRACT Objective To establish a turbidimetric method for the content determination of acetylspiramycin tablets. Method The test organism was Staphylococcus aureus. Adjust the bacterial suspension of Staphylococcus aureus inoculation with about 0.5% (V / V) ratio, at (37 ± 0.5) ℃ for 3.5 ~ 4.5 hours. Results The linear range was 3.2 μ g / ml ~ 15.6 μ g / ml and the average recovery was 100.7% (n = 9); RSD = 1.4%. Conclusion The method was sensitive, rapid, precise and feasible for the determination of Acetylspiramycin tablets. KEY WORDS Potency; Turbidimetric method; Acetylspiramycin tablets Acetylspiramycin yes acetyl spiramycin derivatives, is a semi-synthetic macrolide antibiotics, is a single Acetylspiramycin II, single-and double-Acetylspiramycin III Acetylspiramycin II, double-Acetylspiramycin III four main components of a mixture of low toxicity, adverse reactions is small, more widely and effectively applied to Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, and other infections caused by Neisseria gonorrhoeae [1]. As a result of multi-component Acetylspiramycin antibiotics, the general chemical analysis methods or high-performance liquid chromatography and were unable to determine its content, although literature [2,3] report is available determined by UV spe