Urinary deoxypyridinoline spinal tuberculosis and its clinical significance.docVIP

 PAGE \* MERGEFORMAT 17 Urinary deoxypyridinoline spinal tuberculosis and its clinical significance [Abstract] of spinal tuberculosis (STB) markers of bone metabolism in patients with urinary deoxypyridinoline (DPD) determination to observe the changes of spinal tuberculosis and to evaluate secondary to pulmonary tuberculosis in determining (PTB) diagnosis of spinal tuberculosis screening aspects of clinical significance. [Method] AUTOMATION luminescence immunoassay and automated analysis of spinal tuberculosis group was detected, tuberculosis group and healthy control group, the level of urinary DPD, urinary DPD in urine creatinine which (Cr.) to correct (DPD / Cr.), the effectiveness of the test results for diagnostic analysis. [results] in patients with spinal tuberculosis, tuberculosis patients, healthy controls the determination of DPD values #8203;#8203;were (14.9 + -9.8 μmol / mol Cr., (6.4 + -2.6 μmol / mol Cr. and (6.3 + -2.0 μmol / mol Cr., spinal tuberculosis patients urinary DPD compared with tuberculosis patients, healthy control group was significantly higher, the difference was significant (P = 0.001, P = 0.000). tuberculosis patients and compared to healthy controls, urine DPD test showed no significant (P = 0.751). the urine of patients with spinal tuberculosis detection of the receiver operating characteristics curve DPD (ROC) area under 0.83, under the ROC curve, DPD measured value to 8.4 μmol / mol Cr. for the cut-off point, the diagnostic sensitivity of spinal tuberculosis was 87% and specificity was 73%. [Conclusion] spinal tuberculosis can cause changes in bone metabolism, urinary DPD could reflect the sensitivity of spinal tuberculosis the status of bone resorption, urine DPD test helps spinal tuberculosis secondary to pulmonary tuberculosis in patients with early screening. [Keywords:] spinal tuberculosis Tuberculosis Urinary deoxypyridinoline Abstract: [Objective] To investigate the changes of urinary deoxypyridinoline (DPD) i