Ursolic acid solid dispersion capsules and in vitro dissolution.docVIP

 PAGE \* MERGEFORMAT 19 Ursolic acid solid dispersion capsules and in vitro dissolution 【Abstract】 Objective To evaluate the ursolic acid solid dispersion capsules three kinds of preparations in vitro dissolution rate and quality. Methods PVP-K30 as a water-soluble carrier, solvent prepared by ursolic acid solid dispersion capsule; select 0.5% sodium lauryl sulfate solution as the dissolution medium, the establishment of high-performance liquid chromatography determination of ursolic acid solid dispersion capsules three kinds of preparations in vitro dissolution and the Detection and analysis of ursolic acid in the presence of agents in the state. The results of high-performance liquid chromatography Ursolic acid dissolution, accurate, reliable, stable, non-carrier interference. Within 45 min, ursolic acid solid dispersion capsule in vitro dissolution than tablets increased 2.3-fold increase compared with 1.1 times the physical mixture capsules. Conclusion choose PVP-K30 as a carrier of solid dispersion preparation of ursolic acid capsule can significantly improve the dissolution rate of ursolic acid in vitro. Keywords: ursolic acid, polyvinylpyrrolidone solid dispersion capsule dissolution of high-performance liquid chromatography Abstract: ObjectiveTo evaluate the dissolution in vitro and quality of three kinds of preparations. MethodsUsing PVP  K30 as water soluble carrier, ursolic acid solid dispersion capsule was prepared by a solvent method. The HPLC method for determination of the dissolution in vitro of ursolic acid preparations was established. The existed form of ursolic acid in preparations was detected. ResultsHPLC method was accurate and reliable, and no interference occurred from carriers. The dissolution rate in vitro of ursolic acid solid dispersion capsule increased 2.3 and 1.1 times than tablet and mixture capsule within 45 min, respectively. ConclusionThe solid dispersion capsule with PVP  K30 remarkably improves the