Vascular endothelial growth factor in hypertrophic scar on the role and research.docVIP

 PAGE \* MERGEFORMAT 20 Vascular endothelial growth factor in hypertrophic scar on the role and research [Abstract] hypertrophic scar tissue proliferation and microvessel density are closely related, while the vascular endothelial growth factor is a key regulatory factor microvascular regeneration could promote scar formation of blood vessels, thus contributing to the proliferation of fibroblasts and collagen formation, resulting in scar hyperplasia. [Keywords:] vascular endothelial growth factor in hypertrophic scars Abstract: The formation mechanism of hypertrophic scars is not fully appreciate today, and there is not satisfying the treatment in clinic. With the research progress of molecular biology and cell biology, a large number of people began to study the hypertrophic scar forms molecular mechanism in recent years.Most of them thought that the formation of hypertrophic scars associated with the blood vessel density in hypertrophic scars and the excessive expression of vascular endothelial growth factor and other cytokines. Vascular endothelial growth factor is the key regulatory factor on regeneration of microvascular. VEGF can promote the formation of scar vascular, thereby promote the proliferation of fibroblasts and collagen formation, eventually lead to scar formation. Keywords:: VEGF; Hypertrophic scar Hypertrophic scars (Hypertrophic, HS) is a kind of pathological scar is due to fibroblast proliferation, growth out of control, excessive collagen deposition leading to dermal fibrosis, and over time there is a natural tendency to soften. However, the incidence of underlying mechanisms are not yet entirely clear. Among the many influencing factors, the existing research shows that the extent of scar and microvessel density are closely related, including vascular endothelial growth factor (Vascular endothelial growth factor, VEGF) in physiological and pathological angiogenesis plays a key role in this study VEGF and the relationship between hyp