α lipoic acid on cognitive ability in diabetic rats_0.docVIP

 PAGE \* MERGEFORMAT 13 α lipoic acid on cognitive ability in diabetic rats [Abstract] Objective @ lipoic acid on cognitive ability in diabetic rats, to explore the @ lipoic acid in diabetic rats the mechanisms of learning and memory. Methods 30 Wistar rats were randomly divided into 3 groups, control group 10 only the treatment group 10 in the diabetic group 10. diabetic rats with streptozotocin (STZ) .12 weeks after molding, Morris water maze test of learning and memory ability, western blotting to detect the protein expression of NF κB , TUNEL assay apoptosis of hippocampal neurons. Results In diabetic rats decreased academic performance (P lt;0.05), TUNEL-positive cells increased (P lt;0.05), NF κB protein expression increased (P lt;0.05), @ lipoic acid treated group than the diabetic group increased academic performance (P lt;0.05), TUNEL-positive cells decreased (P lt;0.05), NF κB protein expression was decreased (P lt;0.05). Conclusion The increased expression of NF κB may diabetic rat hippocampal neurons and cognitive dysfunction. @ lipoic acid may be by reducing the expression of NF κB, and thus learning and memory impairment in rats with diabetes have some degree of improvement. [Keywords:] @ LA apoptosis cognitive function in diabetic encephalopathy Diabetes is harmful to human health of the contemporary one of the three diseases, WHO estimated that by 2025 the world could reach 300 million diabetic patients. Diabetes is caused by a variety of chronic complications of diabetes the main reason for death and disability. Past diabetic kidney, heart Complications such as more, while the diabetic encephalopathy (Diabetic encephalopathy) of less is more present as a unique DIABETIC chronic complications of diabetes has been recognized by the medical profession, and gradually become a research hotspot [1]. There studies have shown that diabetic patients with Alzheimer disease (Alzheimer’s disease, AD incidence rate than non-diabetic patients increa