从微生物组到合成功能菌群.PDF

微生物学通报 Apr. 20, 2017, 44(4): 881?889 Microbiology China /wswxtbcn tongbao@ DOI: 10.13344/j.microbiol.china.160603 专论与综述 从微生物组到合成功能菌群 刘炜伟 1,2 吴冰 1 向梅春 1 刘杏忠 1,2* (1. 中国科学院微生物研究所 真菌学国家重点实验室 北京 100101) (2. 中国科学院大学生命科学学院 北京 100049) 摘 要：微生物组是指特定微环境中的微生物群落及其组学，自然界中的生物过程几乎都是通 过微生物组完成的。随着测序技术的发展和成本降低，微生物组已经成为微生物生态学研究的 热点领域。继合成生物学之后，基于微生物组的合成功能菌群研究正在兴起，在人类健康、农 业、工业和生态等领域都有广泛的应用前景。本文从微生物组到合成功能菌群的角度系统论述 了其在不同领域的研究现状与发展趋势，为微生物组从理论研究到应用提供思路。 关键词：微生物群落，功能微生物，合成菌群，生态学，宏组学 From microbiome to synthetic microbial community LIU Wei-Wei1,2 WU Bing1 XIANG Mei-Chun1 LIU Xing-Zhong1,2* (1. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China) (2. School of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China) Abstract: Microbiome describes the microbial community and its -omics that reside in a specific niche, and almost all the biological processes in nature are conducted by certain microbiome. Along with the development and cost effectiveness of DNA sequencing technique, microbiome has become a hot research area. After synthetic biology, synthetic microbial community based on the microbiome will increase our ability to harness the power of microbial communities in biotechnology and to manipulate such communities to promote human health, agriculture, industry and environment. This paper reviews the research progress and application of microbiome in various fields from a viewpoint of ‘from microbiome to synthetic microbial community’, and provides ideas from the th