Comparison of intraoperative frozen section analysis for sentinel lymph node biopsy during breast cancer surgery for invasive lobular carcinoma and invasive ductal carcinoma.docVIP

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Comparison of intraoperative frozen section analysis for sentinel lymph node biopsy during breast cancer surgery for invasive lobular carcinoma and invasive ductal carcinoma.doc

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Comparison of intraoperative frozen section analysis for sentinel lymph node biopsy during breast cancer surgery for invasive lobular carcinoma and invasive ductal carcinoma

World Journal of Surgical Oncology BioMedCentral Research Open Access Comparison of intraoperative frozen section analysis for sentinel lymph node biopsy during breast cancer surgery for invasive lobular carcinoma and invasive ductal carcinoma James W Horvath1, Gary E Barnett1, Rafael E Jimenez1, Donn C Young2 and Stephen P Povoski*3 Address: 1Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA, 2Center for Biostatistics, The Ohio State University, Columbus, Ohio 43210, USA and 3Division of Surgical Oncology, Department of Surgery, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA Email: James W Horvath - james.horvath@; Gary E Barnett - gary.barnett@; Rafael E Jimenez - Jimenez.Rafael@; Donn C Young - young.7@; Stephen P Povoski* - stephen.povoski@ * Corresponding author Published: 24 March 2009 Received: 21 December 2008 Accepted: 24 March 2009 World Journal of Surgical Oncology 2009, 7:34 doi:10.1186/1477-7819-7-34 This article is available from: /content/7/1/34 ? 2009 Horvath et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Sentinel lymph node (SLN) biopsy is the standard of care for the surgical assessment of the axilla during breast cancer surgery. However, the diagnostic accuracy of intraoperative frozen section analysis for confirming metastatic involvement of SLNs in cases of invasive lobular carcinoma (ILC) versus that of invasive ductal carcinoma (IDC) has generated controversy secondary to a frequently low-grade cytologic appearance and an often discohesive pattern displayed by metastatic lymph nodes in ILC. In th