Corneal and Conjunctival Intraepithelial Neoplasia – A Case Report.docVIP

Case Report Corneal and Conjunctival Intraepithelial Neoplasia – A Case Report SarojGupta Department of Ophthalmology, Peoples College of Medical Sciences Research Centre, People’s Campus Bhanpur, Bhopal-462037. Abstract: A65- year old male presented with a reddish mass in left eye with diminution of vision for past four months. Based on clinical examination, a probable diagnosis of ocular surface squamous neoplasia with mature cataract was made. Excision biopsy of the lesion demonstrated intraepithelial neoplasia involving cornea and conjunctiva. Post-operatively patient was put on topical mitomycin –C (0.01%) eye drops 4 times a day for 12 weeks. Cataract surgery was done in the same eye 3 months after cessation of topical Mitomycin-C (MMC) treatment. Follow-up was done for 18 months. Patient’s vision improved to 6/9 in left eye. Key Words: Corneal and conjunctival intraepithelial neoplasia, topical mitomycin C, cryotherapy. Introduction: The Corneal conjunctional intraepithelial neoplasm (CCIN) is an uncommon benign slowly progressive lesion with low malignant potential. Generally it occurs in the inter palpabral fissure, usually at the region of limbus, although it may be found elsewhere. Corneal conjunctional intraepithelial neoplasm may be associated with U-V light exposure, huma n papilloma virus infection, AIDS etc. Management of these lesions includes excision biopsy with adjunctive cryotherapy and topical mitomycin-C (Prabhasawat et al, 2005; Daniell et al, 2002, Sheilds et al, 2002). It is more aggressive and occurs at a younger age in patients with HIV. Here we report the clinicopathological features of CCIN and results of using topical MMC after surgical excision of the neoplasm. Fig. I: Clinical photograph showing a papillary mass on the nasal limbus of the left eye with mature cataract. (Fig. II). irrigation to prevent tumour cell seeding (Fig. II)