Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi.docVIP

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Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi.doc

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Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

Mar. Drugs 2013, 11, 788-799; doi:10.3390/mOPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi Chi-Jen Tai , Jui-Hsin Su 2,3,?, Chiung-Yao Huang , Ming-Shyan Huang 4,5, Zhi-Hong Wen 1, 1,? 1 6 Chang-Feng Dai and Jyh-Horng Sheu 1,7,* 1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mails: jean801023@ (C.-J.T.); betty8575@.tw (C.-Y.H.); wzh@.tw (Z.-H.W.) 2 National Museum of Marine Biology Aquarium, Pingtung 944, Taiwan; E-Mail: x2219@.tw 3 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 4 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan; E-Mail: shyang@.tw 5 Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan 6 Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan; E-Mail: corallab@.tw 7 Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan ? These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: sheu@.tw; Tel.: +886-7-525-2000 (ext. 5030); Fax: +886-7-525-5020. Received: 9 January 2013; in revised form: 6 February 2013 / Accepted: 19 February 2013 / Published: 12 March 2013 Abstract: Five new eunicellin-based diterpenoids, krempfielins E–I (1–5) and seven known compounds (6–12) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. Metabolites 5, 6, 10 and 12 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. Furthermore, compounds 6 and 10 could potently inhibit the