DISTRIBUTION OF SERUM PHOSPHOLIPID FRACTIONS IN PATIENTS WITH DIABETES TYPE 2 AND DYSLIPIDEMIA.docVIP

Original article UDC: 616.379-008.64:577.125 doi:10.5633/amm.2012.0302 DISTRIBUTION OF SERUM PHOSPHOLIPID FRACTIONS IN PATIENTS WITH DIABETES TYPE 2 AND DYSLIPIDEMIA Vesna Vu?i?, Aleksandra Arsi?, Marija Taki?, Danijela Risti?-Medi? and Marija Glibeti? The aim of the present paper was to investigate the serum concentration of total phospholipids and distribution of the phospholipid classes in patients with diabetes mellitus type 2 and dyslipidemia. We analyzed the serum phospholipids in 28 newly diagnosed patients with diabetes type 2, of which 12 men and 16 postmenopausal women aged 43-70 years. Sex- and age-matched control group was formed from 27 apparently healthy subjects. The results showed a significantly higher level of total phospholipids in the patient group when compared with healthy subjects (p0.001). The relative concentration of phosphatidil-choline was significantly higher, and percentages of all other phospholipid classes were significantly lower in the patient group. The obtained results suggest an altered metabolic control of phospholipids in patients with diabetes type 2 with dyslipidemia. Acta Medica Medianae 2012;51(3):13-17. Key words: diabetes mellitus type 2, dyslipidemia, phospholipids, phospholipid classes University of Belgrade, Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, Belgrade, Serbia proteins involved in the transport systems, cell growth, viability, proliferation and apoptosis (1,6). Furthermore, PL serve as a pool of poly- Contact: Vesna Vu?i? unsaturated fatty acids which are precursors of biologically active eicosanoids: prostaglandines, leucotrienes, tromboxanes and lipoxins (7). Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Tadeu?a Ko??u?ka 1, 11129 Beograd E-mail: vesna.vucic.imr@ Due to a correlation with a number of func