Do younger women with non-metastatic and non-inflammatory breast carcinoma have poor prognosis.docVIP

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Do younger women with non-metastatic and non-inflammatory breast carcinoma have poor prognosis.doc

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Do younger women with non-metastatic and non-inflammatory breast carcinoma have poor prognosis

World Journal of Surgical Oncology BioMedCentral Research Open Access Do younger women with non-metastatic and non- inflammatory breast carcinoma have poor prognosis? Aleyamma Mathew*1, Balakrishnan Rajan2 and Manoj Pandey3 Address: 1Division of Epidemiology and Clinical Research, Regional Cancer Centre, Thiruvananthapuram, Kerala, India, 2Division of Radiation Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India and 3Division of Surgical Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India Email: Aleyamma Mathew* - amathew@; Manoj Pandey - manojpandey@; Balakrishnan Rajan - brajan@ * Corresponding author Published: 22 January 2004 Received: 14 February 2003 Accepted: 22 January 2004 World Journal of Surgical Oncology 2004, 2:2 This article is available from: /content/2/1/2 ? 2004 Mathew et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. breast cancerageprognosissurvival Abstract Background: Controversy abounds over whether breast cancer in younger women is more aggressive than those in older. The aim of the study was to assess the influence of age on long-term survival of women with breast carcinoma. Materials and Methods: Patients with non-metastatic and non-inflammatory invasive breast carcinoma treated at the Regional Cancer Centre, Trivandrum, Kerala, India during 1990–93 were divided into 4 age groups as 40 years, 40–49, 50–59, and 60 years. The overall survival (OS) for each age group was estimated using the Kaplan-Meier method in relation to the primary tumor (T) and the axillary node status (N). The OS of the various age groups were compared using the log-rank test. Hazard ratio and 95% confidence interval for each age group was estimated using Cox-regression model after adjusting for T and N