Effect of BDNF and Adipose Derived Stem Cells Transplantation on Cognitive Deficit in Alzheimer Model of Rats.docVIP

Journal of Behavioral and Brain Science, 2013, 3, 156-161 /10.4236/jbbs.2013.31015 Published Online February 2013 (/journal/jbbs) Effect of BDNF and Adipose Derived Stem Cells Transplantation on Cognitive Deficit in Alzheimer Model of Rats Parvin Babaei , Bahram Soltani Tehrani 1,2 1,3 Cellular and Molecular Research Center, Guilan University of Medical Science, Rasht, Iran Department of Physiology, Guilan University of Medical science, Rasht, Iran Department of Pharmacology, Guilan University of Medical science, Rasht, Iran Email: p_babaei@gums.ac.ir, bahram_s_t@ 1 2 3 Received August 29, 2012; revised September 29, 2012; accepted October 19, 2012 ABSTRACT In this study, the potential for recovery mediated by co-treatment of brain-derived neurotrophic factor (BDNF) and adipose tissue derived stem cells (ASCs) on functional recovery after Ibotenic acid (Ibo) lesion of the nucleus basalis magnocellularis (NBM) was examined. Ibotenic acid was injected bilaterally into the NBM of experimental rats, then the animals received treatments as follows: ASCs (500 × 10 ), BDNF (5 ug/ul) and a combination of BDNF and ASCs. 3 Two months after the treatment, cognitive recovery was assessed by the Morris water-maze. These results showed that ASCs transplantation may have therapeutic value in disease and conditions that result in memory loss, and co-treatment with BDNF doesn’t offer more efficacious cognitive function. Keywords: Alzheimer’s Disease; Adipose Stem Cells; Brain-Derived Neurotrophic Factor; Learning and Memory 1. Introduction [10]. A new strategy on manipulating components of the niche that facilitates cross-talk between stem cells and the dysfunctional brain may offer more efficacious neu- rotransplantation [11]. The hypothesis that BDNF pro- motes survival and differentiation of grafted neural stem cells [12,13] triggered us to investigate whether th