Effect of deforolimus and VEGF on angiogenesis in endometrial stromal cells following three-dimensional culture.docVIP

Vol.3, No.1, 7-12 (2013) Stem Cell Discovery /10.4236/scd.2013.31002 Effect of deforolimus and VEGF on angiogenesis in endometrial stromal cells following three-dimensional culture Jafar Ai , Somayeh Ebrahimi , Armin Ai , Roya Karimi , Naghmeh Bahrami 1,2,3,4* 5 6 1 1 1 Department of Tissue Engineering, Faculty of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, * Iran; Corresponding Author: Jafar_ai@tums.ac.ir 2 3 4 5 6 Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran Brain and Spinal Injury Research Center, Imam Hospital, Tehran University of Medical Sciences, Tehran, Iran Cellular and Molecular Research Center, Tehran University of Medical Sciences, Tehran, Iran Department of Biological Science, Faculty of Biology, Kharazmi University (TMU), Tehran, Iran Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Received 4 November 2012; revised 3 December 2012; accepted 2 January 2013 ABSTRACT women and is usually identified in women with pelvic pain and infertility. The etiology and pathogenesis of en- dometriosis is not clearly understood, but there are a number of theories. Historically theories have proposed different reasons for endometriosis including retrograde menstruation, coelomic metaplasia, embryonic rest and lymphovascular metastasis. However, several predisposing factors ranging from genetic to environmental factors as well as physiological and anatomical defects have been reported in correlation with it [1,2]. The human endome- trium develops new capillaries from existing microves- sels, i.e. angiogenesis, which then undergoes maturation and remodeling [3]. Excessive endometrial angiogenesis is suggested to be an important mechan