Effects of the Pharmacological Pre-treatment and Global Brain Ischemia on the Body Temperature in Experimental Rats.docVIP

Marceska et al. Global Brain Ischemia in Rats Macedonian Journal of Medical Sciences. 2008 Dec 15; 1(2):31-35. doi:10.3889/MJMS.1857-5773.2008.0026 Basic Science OPEN2ACCESS Effects of the Pharmacological Pre-treatment and Global Brain Ischemia on the Body Temperature in Experimental Rats Marija Marceska , Marija Soljakova , Saso Panov , Biljana Cvetkovska , Ivica Stefanovski , Andrijan Kartalov 1 1 2 1 1 1 1 2 University Clinic of Anaesthesia, Reanimation and Intensive Care Therapy (UCARICT), Faculty of Medicine; Institute of Biology, Faculty of Natural Sciences and Mathematics, University “Ss. Kiril and Metodij”, Skopje, Republic of Macedonia Abstract The aim of this study is to examine the influence of the pharmacologic pre-treatment and global brain ischemia on the one hand, and on the other hand, the influence of anaesthesia on the body temperature in experimental rats. The study involves 48 white female experimental rats (n=48), strain - Wistar, with body weight ranging from 230 g to 390 g, and age range of 3-5 months. The rats were divided into two groups. All of the rats were anesthetised and underwent various pharmacologic pre-treatments (with erythromycin and physiologic solution) and global brain ischemia with a reperfusion period. The obtained results demonstrate increased body temperature during the anaesthesia, a decrease during ischemia in both groups, and also a significant increase of the temperature 18 hours after the induced global brain ischemia. However, no significant temperature differences were registered between the groups. It can be concluded that the pre-treatment with a single dose of the macrolide antibiotic erythromycin does n