Associations between Methylation of Paternally Expressed Gene 3 (PEG3), Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer.docVIP

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Associations between Methylation of Paternally Expressed Gene 3 (PEG3), Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer.doc

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Associations between Methylation of Paternally Expressed Gene 3 (PEG3), Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer

AssociationsbetweenMethylationofPaternally ExpressedGene3(PEG3),CervicalIntraepithelial NeoplasiaandInvasiveCervicalCancer MonicaD.Nye1,10,CathrineHoyo2,ZhiqingHuang1,AdrianaC.Vidal2,FrancesWang3, FrancineOvercash1,JenniferS.Smith4,BrandiVasquez5,11,BrendaHernandez6,BrittaSwai7, OlolaOneko8,PendoMlay8,JosephObure8,MarilieD.Gammon4,JohnA.Bartlett9,SusanK.Murphy1* 1DivisionofGynecologicOncology,DepartmentofObstetricsandGynecology,DukeUniversitySchoolofMedicine,Durham,NorthCarolina,UnitedStatesofAmerica, 2DepartmentofObstetricsandGynecology,ProgramofCancerDetection,PreventionandControl,DukeUniversitySchoolofMedicine,Durham,NorthCarolina,United States of America, 3Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, North Carolina, United States of America, 4Department of Epidemiology,UniversityofNorthCarolinaatChapelHill,ChapelHill,NorthCarolina,UnitedStatesofAmerica,5KilmanjaroChristianMedicalCenter,Moshi,Tanzania, 6CancerResearchCenterofHawaii,UniversityofHawaii,Honolulu,Hawaii,UnitedStatesofAmerica,7DepartmentofPathology,KilimanjaroChristianMedicalCentre, TumainiUniversity,Moshi,Tanzania,8DepartmentofObstetricsandGynecology,KilimanjaroChristianMedicalCentre,TumainiUniversity,Moshi,Tanzania,9Divisionof InfectiousDiseases,DepartmentofMedicineandDukeGlobalHealthInstitute,DukeUniversitySchoolofMedicine,Durham,NorthCarolina,UnitedStatesofAmerica, 10Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina, United States of America, 11Duke Women’s Health Collaboration,Durham,NorthCarolina,UnitedStatesofAmerica Abstract Cytology-basedscreeningforinvasivecervicalcancer(ICC)lackssensitivityandspecificitytodiscriminatebetweencervical intraepithelialneoplasia(CIN)likelytopersistorprogressfromcaseslikelytoresolve.Genome-wideapproacheshavebeen used toidentify DNA methylation marks associated withCINpersistence orprogression. However, associations between DNAmethylationmarksandCINorICCremainweakandinconsistent.Betwe