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Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis 英文论文文献
GuoandFriedmanFibrogenesisTissueRepair2010,3:21
/content/3/1/21
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Toll-likereceptor4signalinginliverinjuryand
hepaticfibrogenesis
JinshengGuo1,ScottLFriedman2*
Abstract
Toll-likereceptors(TLRs)areafamilyoftransmembranepatternrecognitionreceptors(PRR)thatplayakeyrolein
innateandadaptiveimmunitybyrecognizingstructuralcomponentsuniquetobacteria,fungiandviruses.TLR4is
themoststudiedoftheTLRs,anditsprimaryexogenousligandislipopolysaccharide,acomponentofGram-
negativebacterialwalls.Intheabsenceofexogenousmicrobes,endogenousligandsincludingdamage-associated
molecularpatternmoleculesfr
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