新生儿呼吸窘迫综合征的防治进展.docVIP

Asian Case Reports in Pediatrics 亚洲儿科病例研究, 2013, 1, 10-15 /10.12677/acrp.2013.11003 Published Online February 2013 (/journal/acrp.html) Advantage of Prevention and Treatment in Neonatal Respiratory Distress Syndrome Liming Zhang , Na Wang 1 2 1 2 Department of Neonatal, Weifang People’s Hospital, Affiliate to Weifang Medical College, Weifang Department of Pediatrics, Qilu Children’s Hospital, Ji’nan Email:163.com Received: Jan. 13 , 2013; revised: Jan. 16 , 2013; accepted: Feb. 19 , 2013 th th th Abstract: Neonatal respiratory distress syndrome (NRDS) is caused by deficiency of pulmonary surfactant (PS) in pre- mature infants generally. But it is associated with gestational age, birthweight, asphyxia, caesarean birth, infection, use dexamethasone to mother before delivery, diabetic mother and fetus intrauterine hypoxia. Treated with ambroxol and dexamethasone to maternity before delivery may prevent the NRDS. High dose ambroxol, PS, continuous positive air-way pressure, high-frequency oscillatory ventilation, inhaled NO, liquid ventilation and extracorporeal membrane oxygenation may be used earlier to newborns after birth to avoid aggravation of the disease. Keywords: Prevention; Treatment; Respiratory Distress Syndrome; Newborn 新生儿呼吸窘迫综合征的防治进展 1 张立明，王娜 2 1 2 山东潍坊医学院附属潍坊市人民医院新生儿科，潍坊 山东齐鲁儿童医院儿科，济南 Email:163.com 收稿日期：2013年 1月 13日；修回日期：2013年 1月 16日；录用日期：2013年 2月 19日 摘 要：一般认为，新生儿呼吸窘迫综合征(Neonatal respiratory distress syndrome, NRDS)是由于肺表面活性物质 缺乏所致，近年研究认为 NRDS的发病与胎龄、出生体重、窒息、剖宫产、感染、产前应用肾上腺皮质激素、 糖尿病母亲、宫内慢性缺氧等多种因素有关。为了预防 NRDS的发生，产前可给产妇应用糖皮质激素、氨溴索 等药物，出生后可尽早给予大剂量氨溴索、肺表面活性物质 (Pulmonary surfactant, PS)、持续呼吸道正压通气 (Continuous positive air-way pressure, CPAP)、高频震荡通气(High-frequency oscillatory ventilation, HFOV)、吸入一 氧化氮、液态通气及体外膜肺治疗以阻止病情的进展。 关键词：预防；治疗；呼吸窘迫综合征