Analysis of fMRI Single Subject Data in the Fourier Domain Acquired Using a Multiple Input Stimulus Experimental Design英文文献资料.docVIP

Journal of Signal and Information Processing, 2012, 3, 469-480 /10.4236/jsip.2012.34060 Published Online November 2012 (http://www.SciRP.org/journal/jsip) Analysis of fMRI Single Subject Data in the Fourier Domain Acquired Using a Multiple Input Stimulus Experimental Design Daniel Rio , Robert Rawlings , Lawrence Woltz , Jodi Gilman , Daniel Hommer 1 2* 3 4 1 1 Section of Brain Electrophysiology and Imaging, LCTS, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, USA; National Institute on Alcohol Abuse and Alcoholism, Columbia, USA; Synergy Research Inc., Monrovia, Laboratory of Neuroimaging and Genetics, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 2 3 USA; 4 Charlestown, USA. Email: drio@ Received July 28 , 2012; revised August 27 , 2012; accepted September 12 , 2012 th th th ABSTRACT Analysis of functional MRI (fMRI) blood oxygenation level dependent (BOLD) data is typically carried out in the time domain where the data has a high temporal correlation. These analyses usually employ parametric models of the hemo- dynamic response function (HRF) where either pre-whitening of the data is attempted or autoregressive (AR) models are employed to model the noise. Statistical analysis then proceeds via regression of the convolution of the HRF with the input stimuli. This approach has limitations when considering that the time series collected are embedded in a brain image in which the AR model order may vary and pre-whitening techniques may be insufficient for handling faster sampling times. However fMRI data can be analyzed in the Fourier dom