Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal Women英文文献资料.docVIP
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Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal Women英文文献资料
SAGE-HindawiAccesstoResearch
CardiologyResearchandPractice
Volume2011,ArticleID904878,9pages
doi:10.4061/2011/904878
ResearchArticle
AndroidalFatDominatesinPredictingCardiometabolicRiskin
PostmenopausalWomen
O.A.Matvienko,
2
1
D.L.Alekel,
2
S.N.Bhupathiraju, H.Hofmann, L.M.Ritland,
2 3 2
andC.D.Perry
M.B.Reddy, M.D.VanLoan,
4
2
1
SchoolofHealth,PhysicalEducationandLeisureServices,133Wellness/RecreationCenter,UniversityofNorthernIowa,
CedarFalls,IA50614-0241,USA
2
3
4
FoodScienceandHumanNutrition,HumanNutritionalSciencesBuilding,IowaStateUniversity,Ames,IA50011-1123,USA
DepartmentofStatistics,2413Snedecor/2624CHowe,IowaStateUniversity,Ames,IA50011,USA
WesternHumanNutritionResearchCenter,UniversityofCalifornia,Davis,CA95616,USA
CorrespondenceshouldbeaddressedtoO.A.Matvienko,oksana.matvienko@
Received14September2010;Revised4November2010;Accepted24November2010
AcademicEditor:ChristinaChrysohoou
Copyright?2011O.A.Matvienkoetal. This is an open access article distributed under the Creative Commons Attribution
License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly
cited.
Wehypothesizedthatsoyiso?avoneswouldattenuatetheanticipatedincreaseinandroidalfatmassinpostmenopausalwomen
duringthe36-monthtreatment,andtherebyfavorablymodifythecirculatingcardiometabolicriskfactors:triacylglycerol,LDL-
C, HDL-C, glucose, insulin, uric acid, C-reactive protein, ?brinogen, and homocysteine. We collected data on 224 healthy
postmenopausalwomenatriskforosteoporosis(45.8–65y,medianBMI24.5)whoconsumedplaceboorsoyiso?avones(80
or120mg/d)for36monthsandusedlongitudinalanalysistoexaminethecontributionofiso?avonetreatment,androidalfat
mass,otherbiologicfactors,anddietaryqualitytocardiometabolicoutcomes.Exceptforhomocysteine,eachcardiometabolic
outcomemodelwassigni?cant(overallP-valuesfrom≤.0001to.0028).Androidalfatmasswastypicallythestrongestcovariate
ineachmodel.Iso?avonetreatmentdidnotin?uenceanyoftheoutcomes.
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