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Antibiotic Combinations with Daptomycin for Treatment of Staphylococcus aureus Infections英文文献资料.doc

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Antibiotic Combinations with Daptomycin for Treatment of Staphylococcus aureus Infections英文文献资料

HindawiPublishingCorporation ChemotherapyResearchandPractice Volume2011,ArticleID619321,10pages doi:10.1155/2011/619321 ReviewArticle AntibioticCombinationswithDaptomycinforTreatmentof StaphylococcusaureusInfections KristinaNadrahandFrancStrle DepartmentofInfectiousDiseases,UniversityMedicalCentreLjubljana,Japljeva2,1525Ljubljana,Slovenia CorrespondenceshouldbeaddressedtoKristinaNadrah,kristina.nadrah@kclj.si Received19November2010;Accepted23January2011 AcademicEditor:AthanassiosTsakris Copyright?2011K.NadrahandF.Strle. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. DaptomycinisalipopeptideantibioticwithauniquemechanismofactiononGram-positivebacteria.Itisapprovedfortreatment of skin and soft-tissue infections with Gram-positive bacteria, bacteraemia and right-sided infective endocarditis caused by Staphylococcus aureus. Diminishing susceptibility ofS. aureus to daptomycin during treatment of complicated infections and clinicalfailurehavebeendescribed.Combinationsofdaptomycinwithotherantibioticsincludinggentamicin,rifampin,beta- lactams,trimethoprim/sulfamethoxazole(TMP-SMX),orclarithromycinpresentanewapproachfortherapy.Invitroandanimal studieshaveshownthatsuchcombinationsmay,insomecases,besuperiortodaptomycinmonotherapy.Inthispaperwefocus ontheantibioticcombinationsforcomplicatedS.aureusinfections. 1.Introduction causedbyGram-positivebacteria,andforS.aureusbacter- aemiaandright-sidedendocarditis[1].Itisnotactiveinlow respiratory tract infections, because lung surfactant forms complexeswithdaptomycintherebyinactivatingit[2]. Daptomycin mechanism of action is complex and not entirely understood. Research so far indicates that it acts oncell membrane [3, 4] and also inhibits the synthesis of lipoteichoicacid,necessaryforcellwallsynthesis[4]. Daptomycin structure consists of an anionic core and Daptomycin,anantibioti