Antioxidant Activities and Inhibitory Effects of Auricularia Auricular and Its Functional Formula Diet Against Vascular Smooth Muscle Cell in Vitro英文文献资料.docVIP

Food and Nutrition Sciences, 2011, 2, 265-271 doi:10.4236/fns.2011.24038 Published Online June 2011 (/journal/fns) Antioxidant Activities and Inhibitory Effects of Auricularia Auricular and Its Functional Formula Diet against Vascular Smooth Muscle Cell in Vitro Yangchao Luo , Zhenlei Xiao , Qin Wang , Bo Li , Baoping Ji 1 1 1 2 2 1 2 Department of Nutrition and Food Science, University of Maryland, College Park, US; College of Food Science and Nutritional Engineer- ing, China Agricultural University, Beijing, China. Email: libo@ Received January 12 , 2011; revised February 25 , 2011; accepted March 1 , 2011. th th st ABSTRACT The functional formula diet AHP, containing polysaccharides from Auricularia auricular, polyphenolic compounds from Hawthorn (Crataegus) and Pueraria radix, has been recently developed as a dietary intervention against dyslipi- demia in our previous study. In the present study, its antioxidant activities and protective effects against proliferation of vascular smooth muscle cells (VSMCs) were investigated. AHP possessed the potent radical-scavenging effects against hydroxyl and superoxide radicals, and also the inhibitory effects against peroxidation of low density lipoprotein in- duced by Cu2+ in vitro. The protective effects of AHP against proliferation of VSMCs were evaluated through the meth- odology of serum pharmacology. The serum containing AHP significantly inhibited the proliferation of VSMCs induced by oxidized low density lipoprotein in a time- and dose-dependent manner