Autoantibodies to Tailor-Made Panels of Tumor-Associated Antigens in Breast Carcinoma英文文献资料.docVIP

Autoantibodies to Tailor-Made Panels of Tumor-Associated Antigens in Breast Carcinoma英文文献资料.doc

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Autoantibodies to Tailor-Made Panels of Tumor-Associated Antigens in Breast Carcinoma英文文献资料

HindawiPublishingCorporation JournalofOncology Volume2011,ArticleID982425,7pages doi:10.1155/2011/982425 ReviewArticle AutoantibodiestoTailor-MadePanelsofTumor-Associated AntigensinBreastCarcinoma EttiePiura andBenjaminPiura 1 2 1 DepartmentofObstetricsandGynecology,SapirMedicalCenter,SacklerSchoolofMedicine,UniversityofTel-Aviv, Kfar-Saba44281,Israel 2 UnitofGynecologicOncology, Department ofObstetrics andGynecology, SorokaMedicalCenterandFacultyofHealthSciences, Ben-GurionUniversityoftheNegev,Beer-Sheva84101,Israel CorrespondenceshouldbeaddressedtoBenjaminPiura,piura@bgu.ac.il Received31October2010;Accepted14January2011 AcademicEditor:AysegulaA.Sahin Copyright?2011E.PiuraandB.Piura. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Autoantibodies(AAbs)totumor-associatedantigens(TAAs)havebeen identi?edintheseraofcancerpatients.Inaprevious reviewpublishedinthisjournal,wehavefocusedonrecentknowledgerelatedtocirculatingAAbstoindividualTAAsinbreast carcinoma.ThisreviewwillfocusonrecentknowledgerelatedtoAAbassaystotailor-madepanelsofTAAsinbreastcarcinoma. Sofar,AAbassaystothefollowingtailor-madepanelsofTAAshavebeenassessedinbreastcarcinoma:(1)p53,c-myc,HER2,NY- ESO-1,BRCA2,andMUC1,(2)IMP1,p62,Koc,p53,c-MYC,cyclinB1,andsurvivin,(3)PPIA,PRDX2,FKBP52,HSP-60,and MUC1,(4)MUC1,HER2,p53,andIGFBP2,(5)p53,HER2,IGFBP-2,andTOPO2α,(6)survivinandlivin,(7)ASB-9,SERAC1, andRELT,and(8)p16,p53,andc-myc.AssessmentofserumAAbstoatailor-madepanelofTAAsprovidesbettersensitivity todiagnosisofbreastcarcinomathanmeasuringserumAAbstoasingleTAA.Nevertheless,measurementofserumAAbstoa panelofTAAsforscreeningandearlydiagnosisofbreastcarcinomaisstillinvestigationalandshouldbecarriedoutalongwith traditionaldiagnosticstudies. 1.Introduction 207,090withanage-adjustedincidenceof121.8per100,000 women[4].Thenumberofwomendeadofbreas

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