Autoantibodies to Tailor-Made Panels of Tumor-Associated Antigens in Breast Carcinoma英文文献资料.docVIP
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Autoantibodies to Tailor-Made Panels of Tumor-Associated Antigens in Breast Carcinoma英文文献资料
HindawiPublishingCorporation
JournalofOncology
Volume2011,ArticleID982425,7pages
doi:10.1155/2011/982425
ReviewArticle
AutoantibodiestoTailor-MadePanelsofTumor-Associated
AntigensinBreastCarcinoma
EttiePiura andBenjaminPiura
1 2
1
DepartmentofObstetricsandGynecology,SapirMedicalCenter,SacklerSchoolofMedicine,UniversityofTel-Aviv,
Kfar-Saba44281,Israel
2
UnitofGynecologicOncology, Department ofObstetrics andGynecology, SorokaMedicalCenterandFacultyofHealthSciences,
Ben-GurionUniversityoftheNegev,Beer-Sheva84101,Israel
CorrespondenceshouldbeaddressedtoBenjaminPiura,piura@bgu.ac.il
Received31October2010;Accepted14January2011
AcademicEditor:AysegulaA.Sahin
Copyright?2011E.PiuraandB.Piura. This is an open access article distributed under the Creative Commons Attribution
License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly
cited.
Autoantibodies(AAbs)totumor-associatedantigens(TAAs)havebeen identi?edintheseraofcancerpatients.Inaprevious
reviewpublishedinthisjournal,wehavefocusedonrecentknowledgerelatedtocirculatingAAbstoindividualTAAsinbreast
carcinoma.ThisreviewwillfocusonrecentknowledgerelatedtoAAbassaystotailor-madepanelsofTAAsinbreastcarcinoma.
Sofar,AAbassaystothefollowingtailor-madepanelsofTAAshavebeenassessedinbreastcarcinoma:(1)p53,c-myc,HER2,NY-
ESO-1,BRCA2,andMUC1,(2)IMP1,p62,Koc,p53,c-MYC,cyclinB1,andsurvivin,(3)PPIA,PRDX2,FKBP52,HSP-60,and
MUC1,(4)MUC1,HER2,p53,andIGFBP2,(5)p53,HER2,IGFBP-2,andTOPO2α,(6)survivinandlivin,(7)ASB-9,SERAC1,
andRELT,and(8)p16,p53,andc-myc.AssessmentofserumAAbstoatailor-madepanelofTAAsprovidesbettersensitivity
todiagnosisofbreastcarcinomathanmeasuringserumAAbstoasingleTAA.Nevertheless,measurementofserumAAbstoa
panelofTAAsforscreeningandearlydiagnosisofbreastcarcinomaisstillinvestigationalandshouldbecarriedoutalongwith
traditionaldiagnosticstudies.
1.Introduction
207,090withanage-adjustedincidenceof121.8per100,000
women[4].Thenumberofwomendeadofbreas
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