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Baroreflex Activation Therapy for the Treatment of Drug-Resistant Hypertension New Developments英文文献资料.doc

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Baroreflex Activation Therapy for the Treatment of Drug-Resistant Hypertension New Developments英文文献资料

HindawiPublishingCorporation CardiologyResearchandPractice Volume2012,ArticleID587194,7pages doi:10.1155/2012/587194 ReviewArticle Barore?exActivationTherapyfortheTreatmentof Drug-ResistantHypertension:NewDevelopments TebaAlnima,PeterW.deLeeuw,andAbrahamA.Kroon DepartmentofInternalMedicine,MaastrichtUniversityMedicalCenter,P.Debyelaan25,6229HXMaastricht,TheNetherlands CorrespondenceshouldbeaddressedtoAbrahamA.Kroon,aa.kroon@mumc.nl Received13February2012;Accepted23April2012 AcademicEditor:AndrejsErglis Copyright?2012TebaAlnimaetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Inthepastfewyears,novelaccomplishmentshavebeenobtainedincarotidbarore?exactivationtherapy(BAT)forthetreatment ofresistanthypertension.Inaddition,this?eldisstillevolvingwithpromisingresultsinthereductionofbloodpressureandheart rate.ThisoverviewaddressesthelatestdevelopmentsinBATforthetreatmentofdrug-resistanthypertension.Althoughnottotally understoodconsideringtheworkingmechanismsofBAT,itappearedtobepossibletoachieveatleastasmuche?cacyofsingle- sidedasbilateralstimulation.Thereforeunlikethe?rst-generationRheossystem,thesecond-generationBarostimneooperates byunilateralbarore?exactivation,usingacompletelydi?erentcarotidelectrode.Alsosigni?cantimprovementsinseveralcardiac parametershavebeenshownbyBATinhypertensivepatients,whichsetthebasisforfurtherresearchtoevaluateBATasatherapy forsystolicheartfailure.Yetimportantuncertaintiesneedtobeclari?edtoguaranteebene?ciale?ects;hencenotallparticipants seemtorespondtoBAT. 1.Introduction 2. CarotidBaroreceptorsand MechanismsofBAT The urgent need for treatments for drug-resistant hyper- tension has engendered great interest in the development of new approaches. Carotid barore?ex activation is a rela- tivelynoveltherapyfordrug-resistanthypertension.Several trials have demonstrated the safety and e?cacy of this method in