Behavioral Predictors of Colonization with Lactobacillus crispatus or Lactobacillus jensenii after Treatment for Bacterial Vaginosis A Cohort Study英文文献资料.docVIP

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Behavioral Predictors of Colonization with Lactobacillus crispatus or Lactobacillus jensenii after Treatment for Bacterial Vaginosis A Cohort Study英文文献资料.doc

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Behavioral Predictors of Colonization with Lactobacillus crispatus or Lactobacillus jensenii after Treatment for Bacterial Vaginosis A Cohort Study英文文献资料

HindawiPublishingCorporation InfectiousDiseasesinObstetricsandGynecology Volume2012,ArticleID706540,6pages doi:10.1155/2012/706540 ResearchArticle BehavioralPredictorsofColonizationwith LactobacilluscrispatusorLactobacillusjenseniiafter TreatmentforBacterialVaginosis:ACohortStudy CarolineMitchell, LisaE.Manhart, KathyThomas, TinaFiedler, 1 2 3 4 DavidN.Fredricks,3,4andJeanneMarrazzo3 1 HarborviewWomen’sClinic,DepartmentofObstetricsGynecology,UniversityofWashington,3259thAvenue, Seattle,WA98105,USA 2 3 4 DepartmentofEpidemiology,UniversityofWashington,Seattle,WA98195,USA DepartmentofMedicine,UniversityofWashington,Seattle,WA98195,USA FredHutchinsonCancerResearchCenter,USA CorrespondenceshouldbeaddressedtoCarolineMitchell,camitch@ Received12February2012;Accepted5April2012 AcademicEditor:BryanLarsen Copyright?2012CarolineMitchelletal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Objective:Evaluatepredictorsofvaginalcolonizationwithlactobacilliaftertreatmentforbacterialvaginosis(BV).Methods .Vaginal ?uidspecimensfromwomenwithBVunderwentqPCRforLactobacilluscrispatus,L.jensenii,andL.inerspre-andposttreatment. Results.FewwomenwithBVwerecolonizedwithL.crispatus(4/44,9%)orL.jensenii(1/44,2%),thoughallhadL.iners.One monthposttreatment12/44(27%)hadL.crispatus,12/44(27%)L.jensenii,and43/44(98%)L.iners.PresenceofL.jensenii posttreatmentwasassociatedwithcure(RiskRatio(RR)1.67;95%CI1.09–2.56);L.crispatusshowedasimilartrend(RR1.41;95% CI0.89–2.24,P=0.14).Receptiveoralsexwasassociatedwith2.2-log10lowerconcentrationofL.crispatus(95%CI?4.38,?.02), anddigital-vaginalsexwith2.6-log lowerconcentration(95%CI?4.87,?.33).Conclusion.OnemonthafterBVtreatment,few 10 womenestablishedcolonizationwithL.crispatusorL.jensenii.Fewbehaviorswereassociatedwithcolonization. 1.Introduction tonon-H2O2-p