Associations of Plasma Phospholipid Omega-6 and Omega-3 Polyunsaturated Fatty Acid Levels and MRI Measures of Cardiovascular Structure and Function The Multiethnic Study of Atherosclerosis英文文献资料.docVIP

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Associations of Plasma Phospholipid Omega-6 and Omega-3 Polyunsaturated Fatty Acid Levels and MRI Measures of Cardiovascular Structure and Function The Multiethnic Study of Atherosclerosis英文文献资料.doc

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Associations of Plasma Phospholipid Omega-6 and Omega-3 Polyunsaturated Fatty Acid Levels and MRI Measures of Cardiovascular Structure and Function The Multiethnic Study of Atherosclerosis英文文献资料

HindawiPublishingCorporation JournalofNutritionandMetabolism Volume2011,ArticleID315134,9pages doi:10.1155/2011/315134 ResearchArticle AssociationsofPlasmaPhospholipidOmega-6and Omega-3PolyunsaturatedFattyAcidLevelsandMRIMeasuresof CardiovascularStructureandFunction:TheMultiethnic StudyofAtherosclerosis JenniferS.Anderson, MichaelY.Tsai, LynM.Steffen, MartinR.Prince, andDavidHerrington 1 JenniferA.Nettleton, 3 2 W.GregoryHundley, DavidSiscovick, Jo?aoLima, 4 5 1 3 RozennN.Lemaitre, 4 6 1 1 2 DivisionofCardiology,DeparmentofInternalMedicine,WakeForestUniversity,Winston-Salem,NC27157,USA Division ofEpidemiology,HumanGenetics andEnvironmentalSciences, UniversityofTexasHealthSciences CenteratHouston, Houston,TX77030,USA 3 4 5 6 DivisionofEpidemiologyandCommunityHealth,UniversityofMinnesota,Minneapolis,MN55455,USA DepartmentsofMedicineandEpidemiology,UniversityofWashington,Seattle,WA98105,USA DivisionofCardiology,DepartmentofMedicine,JohnsHopkinsUniversity,Baltimore,MD2187-0020,USA DepartmentofRadiology,ColumbiaCollegeofPhysiciansandSurgeons,NewYork,NY10032,USA CorrespondenceshouldbeaddressedtoJenniferS.Anderson,jeanders@ Received16March2011;Revised12June2011;Accepted29June2011 AcademicEditor:AliceOwen Copyright?2011JenniferS.Andersonetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Background.Theassociationbetweenplasmaomega-6fattyacidsandcardiovasculardisease(CVD)isunclear,anddiscrepancy remainsconcerningthecardiovascularbene?toftheomega-3fattyacidalpha-linolenicacid.Methods.Associationsofplasma phospholipidfattyacidlevels(arachidonicacid,linoleicacid,eicosapentaenoicacid,docosahexaenoicacid(DHA),andalpha- linolenicacid)withcardiacmagneticresonanceimagingmeasuresofleftventricular(LV)mass,LVvolume,ejectionfraction, stroke volume, and aortic distensibility were investigated in 1,274 adults. Results. Results of m