Behavioral Evidence for Cognitive Dysfunctions in the (BALBcByJ-Kv1.1mcephmceph) Mouse Model for Epilepsy英文文献资料.docVIP

Journal of Behavioral and Brain Science, 2011, 1, 210-228 doi:10.4236/jbbs.2011.14028 Published Online November 2011 (http://www.SciRP.org/journal/jbbs) Behavioral Evidence for Cognitive Dysfunctions in the (BALB/cByJ-Kv1.1mceph/mceph) Mouse Model for Epilepsy Sarah Holst , Elin ?berg , Therese M. Eriksson , Catharina Lavebratt , Sven Ove ?gren 1,4 2 3 2 1 1 Department of Neuroscience, Karolinska Institute, Stockholm, Sweden Department of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden Center of Molecular Medicine, Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden E-mail: Sarah.Holst@ki.se 2 3 4 Received July 25, 2011; revised August 16, 2011; accepted September 5, 2011 Abstract The epileptic mouse model BALB/cByJ-Kv1.1 mceph/mceph (mceph/mceph) is homozygous for a spontaneous mutation truncating the Shaker-like voltage gated potassium channel, Kv1.1 (Kcna1). The mceph/mceph mice are asymptomatic at birth, but develop from 3 weeks of age epileptic seizures, overgrowth and neuronal hyperplasia of the hippocampus. Hippocampal cognitive function of the mice was examined by investigating emotional memory using the aversive Passive Avoidance (PA) task combined with studies of explorative behavior using the non-aversive Novel Cage test (NCT). The behavioural results were examined by multi- variate analysis. Compared to wild type and heterozygous mice, the mceph/mceph mice displayed lower ex- ploratory and safety assessment behavior in the NCT and impairment in PA retention 24 hours after training, indicating an impairment in cognitive functions. In conclusion, the epileptic mouse model BAL