Behavioral inhibition in female college students with schizotypal traits An event-related potential study英文文献资料.docVIP

Open Journal of Psychiatry, 2012, 2, 362-369 OJPsych /10.4236/ojpsych.2012.224051 Published Online November 2012 (http://www.SciRP.org/journal/ojpsych/) Behavioral inhibition in female college students with schizotypal traits: An event-related potential study Ji-Hyun Lee, Myung-Sun Kim * Department of Psychology, Sungshin Women’s University, Seoul, South Korea * Email: kimms@sungshin.ac.kr Received 30 August 2012; revised 29 September 2012; accepted 8 October 2012 ABSTRACT schizophrenia using the Go/NoGo task have reported that schizophrenia patients show significantly longer re- sponse times in response to Go stimuli [2] and more er- rors in response to NoGo stimuli than normal controls [3]. This indicates that patients with schizophrenia have defi- cits in behavioral inhibition. This study investigated behavioral inhibition in fe- male college students with psychometrically defined schizotypal traits using a Go/NoGo task and event- related potentials (ERPs). The schizotypal-trait (n = 15) and normal control (n = 15) groups were selected based on scores of the Schizotypal Personality Ques- tionnaire (SPQ). The Go/NoGo task consisted of Go (requires response) and NoGo (requires no response) conditions. In terms of response time and accuracy rate for the Go/NoGo task, the two groups did not differ significantly. In terms of ERPs, the control group showed greater N2 amplitudes in response to NoGo (NoGo-N2) than to Go stimuli (Go-N2), where- as the schizotypal-trait group showed no significant difference in NoGo-N2 and Go-N2 amplitudes. In addition, the schizotypal-trait group showed reduced NoGo-N2 amplitudes at the frontal site compared to controls, and an association between SPQ scores and NoGo-N2 amplitudes measured at the frontal site. The two groups did not differ in P3 amplitudes. Since the N2 reflects the detection of response conflict and behavioral inhibitio