Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism英文文献资料.docVIP

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Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism英文文献资料.doc

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Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism英文文献资料

HindawiPublishingCorporation Evidence-BasedComplementaryandAlternativeMedicine Volume2011,ArticleID924851,10pages doi:10.1155/2011/924851 ResearchArticle BerberineModeratesGlucoseandLipidMetabolismthrough MultipathwayMechanism QianZhang,XinhuaXiao,KaiFeng,TongWang,WenhuiLi,TaoYuan,XiaofangSun,QiSun, HongdingXiang,andHengWang DepartmentofEndocrinology,PekingUnionMedicalCollegeHospital,ChineseAcademyofMedicalSciences,Beijing100730,China CorrespondenceshouldbeaddressedtoXinhuaXiao,xiaoxinhua@andKaiFeng,fengkai@ Received7May2010;Accepted21August2010 Copyright?2011QianZhangetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Berberineisknowntoimproveglucoseandlipidmetabolismdisorders,butthemechanismisstillunderinvestigation.Inthis paper,weexploredthee?ectsofberberineontheweight,glucoselevels,lipidmetabolism,andseruminsulinofKKAymiceand investigateditspossibleglucoseandlipid-regulatingmechanism.WerandomlydividedKKAymiceintotwogroups:berberine group (treated with 250mg/kg/d berberine) and control group. Fasting blood glucose (FBG), weight, total cholesterol (TC), triglyceride(TG),high-densitylipoprotein-cholesterol(HDL-c),low-densitylipoprotein-cholesterol(LDL-c),andfastingserum insulinweremeasuredinbothgroups.Theoralglucosetolerancetest(OGTT)wasperformed.RT PCRarraygeneexpression 2 analysis was performed using skeletal muscle of KKAy mice. Our data demonstrated that berberine signi?cantly decreased FBG,areaunderthecurve(AUC),fastingseruminsulin(FINS),homeostasismodelassessmentinsulinresistance(HOMA-IR) 2 index,TC,andTG,comparedwiththoseofcontrolgroup.RT pro?lerPCRarrayanalysisshowedthatberberineupregulated the expression of glucose transporter 4 (GLUT4), mitogen-activated protein kinase 14 (MAPK14), MAPK8(c-jun N-terminal kinase,JNK),peroxisomeproliferator-activatedreceptorα(PPARα),uncouplingprotein2(UCP2),andhepaticnucle