Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans英文文献资料.docVIP

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Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans英文文献资料.doc

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Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans英文文献资料

SAGE-HindawiAccesstoResearch InternationalJournalofIn?ammation Volume2011,ArticleID936109,9pages doi:10.4061/2011/936109 ResearchArticle AtheroscleroticPlaqueStabilityIsAffectedby theChemokineCXCL10inBothMiceandHumans DolfSegers, 1 JonathanA.Lipton, 3 1 PieterJ.M.Leenen, CarolineCheng, DennieTempel, 2 1 1 RinideCrom, andRobKrams 6 GerardPasterkamp, FransL.Moll, 4 5 1 2 3 4 5 6 DepartmentofCardiology,ErasmusUniversityMedicalCenter,3522ZZRotterdam,TheNetherlands DepartmentofImmunology,ErasmusUniversityMedicalCenter,3522ZZRotterdam,TheNetherlands DepartmentofCardiology,UniversityMedicalCenter-Utrecht,3584CXUtrecht,TheNetherlands DepartmentofVascularSurgery,UniversityMedicalCenter-Utrecht,3584CXUtrecht,TheNetherlands DepartmentofCellBiologyandGenetics,ErasmusUniversityMedicalCenter,3522ZZRotterdam,TheNetherlands DepartmentofBioengineering,RoyalSchoolofMines,ImperialCollege,LondonSW72AZ,UK CorrespondenceshouldbeaddressedtoRobKrams,r.krams@imperial.ac.uk Received29June2011;Accepted25August2011 AcademicEditor:ElenaAikawa Copyright?2011DolfSegersetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Background.ThechemokineCXCL10isspeci?callyupregulatedduringexperimentaldevelopmentofplaquewithanunstable phenotype.Inthisstudyweevaluatedthefunctionalconsequencesofthese?ndingsinmiceandhumans.MethodsandResults .In ApoE ?/?mice,weinducedunstableplaquewithusinga?ow-alteringdevicearoundthecarotidartery.Fromweek1to4,mice wereinjectedwithaneutralizingCXCL10antibody.After9weeks,CXCL10inhibitionresultedinamorestableplaquephenotype: collagenincreasedby58%(P = 0.002),smoothmusclecellcontentincreased2-fold(P = 0.03),whilemacrophageMHCclass IIexpressiondecreasedby50%(P =0.005).Also,thesizeofnecroticcoresdecreasedby41%(P =0.01).In106humancarotid endarterectomyspecimenswefoundthatincreasingconcentrationsofC