Biodistribution of 60Co–CoGraphitic-Shell Nanocrystals In Vivo英文文献资料.docVIP

HindawiPublishingCorporation JournalofNanomaterials Volume2011,ArticleID842613,5pages doi:10.1155/2011/842613 ResearchArticle Biodistributionof60Co–Co/Graphitic-ShellNanocrystalsInVivo LiZhan, QiWei, GengYanxia, XuJunzheng, 1 1 1 1andWuWangsuo 1,2 1 2 RadiochemistryLaboratory,SchoolofNucleraScienceandTechnology,LanzhouUniversity,Lanzhou73000,China StateKeyLaboratoryofAppliedOrganicChemistry,LanzhouUniversity,Lanzhou730000,China CorrespondenceshouldbeaddressedtoWuWangsuo,wuws@ Received21February2011;Revised12April2011;Accepted23May2011 AcademicEditor:XingJ.Liang Copyright?2011LiZhanetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,which permitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Themagneticnano-materials,Co/graphiticcarbon-(GC-)shellnanocrystals,weremadeviachemicalvapourdeposition(CVD) 60 method,andtheirbiodistributionandexcretioninmicewerestudiedbyusingpostintravenously(i.v.)injectingwith Co–Co/GC nanocrystals.Theresultsshowedthatabout5%ofCowasembeddedintographiticcarbontoformmultilayerCo/GCnanocrystals andthesizeoftheparticlewas ～20nm,thethicknessofthenanocrystalcoverlayerwas ～4nm,andthecoresizeofCowas ～14nm.Mostofthenanocrystalswereaccumulatedinlung,liver,andspleenafter6,12,18,and24hafteri.v.with Co–Co/GC 60 nanocrystals.Thenanoparticleswereclearedrapidlyfrombloodandclosedtolowerlevelin10minafterinjection.The 60 Co– Co/GCnanocrystalswereeliminatedslowlyfrombodyin24hafterinjection,～6.09%of Co–Co/GCnanocrystalswereexcreted 60 byurine,～1.85%byfecesin24h,andthetotalexcretionwaslessthan10%. 1.Introduction into metals/GC nanocrystals, and which can be used as drugcarrierandintermediateinradiationmedicine?elds. Thereby,asanewdrugcarrierwithadvancedmagneticand radioactive, it would be selectively localized to the target- siteoftumorandfocusbyexternalmagnetic?eld,andthen, thedrugandgammaraywouldbedeliveredtocellandkil