Blockade of Cochlear NMDA Receptors Prevents Long-Term Tinnitus during a Brief Consolidation Window afterewline Acoustic Trauma英文文献资料.docVIP

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Blockade of Cochlear NMDA Receptors Prevents Long-Term Tinnitus during a Brief Consolidation Window afterewline Acoustic Trauma英文文献资料.doc

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Blockade of Cochlear NMDA Receptors Prevents Long-Term Tinnitus during a Brief Consolidation Window afterewline Acoustic Trauma英文文献资料

HindawiPublishingCorporation NeuralPlasticity Volume2007,ArticleID80904,11pages doi:10.1155/2007/80904 ResearchArticle BlockadeofCochlearNMDAReceptorsPrevents Long-TermTinnitusduringaBriefConsolidationWindow afterAcousticTrauma MatthieuJ.Guitton1,2,3andYadinDudai1 1 2 DepartmentofNeurobiology,TheWeizmannInstituteofScience,Rehovot76100,Israel MolecularEndocrinologyandOncologyResearchCenter,LavalUniversityMedicalCenter(CHUL),QuebecCity, QC,CanadaG1V4G2 3 FacultyofPharmacy,LavalUniversity,QuebecCity,QC,CanadaG1K7P4 CorrespondenceshouldbeaddressedtoMatthieuJ.Guitton,matthieu.guitton@pha.ulaval.ca Received29September2007;Accepted12December2007 RecommendedbyZygmuntGaldzicki Tinnitus,theperceptionofsoundintheabsenceofexternalacousticstimulation,isacommonanddevastatingpathology.Itis oftenaconsequenceofacoustictraumaordrugtoxicity.Theneuronalmechanismsoftinnitusareneitheryetfullyunderstood noraree?ectivetreatmentsavailable.Usinganovelbehavioralparadigmformeasuringtinnitusintheratbasedontone-guided navigation,weshowherethatthedevelopmentoflong-termnoise-inducedtinnitus,themostprevalentandclinicallyimportant formofhumantinnitus,canbeabatedbylocaladministrationoftheNMDAantagonist“ifenprodil”intothecochleainthe?rst 4daysfollowingthenoiseinsultbutnotafterwards.Thissuggeststhatlong-termtinnitusundergoesaconsolidation-likeprocess, resemblingtheontogenyofitemsinlong-termmemory.Furthermore,this?ndingpavesthewaytopotentialtherapeuticstrategies forthepreventionofchronictinnitusoncethenoiseinsulthadtakenplace. Copyright?2007M.J.GuittonandY.Dudai.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. 1. INTRODUCTION sharedwiththosethatsubservememory?Evidencehasbeen accumulatedtoimplicateneuroplasticityintinnitus,includ- ing a role for cochlear N-methyl-D-aspartate (NMDA) re- ceptor[7,11,12]. Moststudiesusesalicylate-inducedtinnitusasamodel. Thisformaccoun