Blueberry Extracts Protect Testis from Hypobaric Hypoxia Induced Oxidative Stress in Rats英文文献资料.docVIP

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Blueberry Extracts Protect Testis from Hypobaric Hypoxia Induced Oxidative Stress in Rats英文文献资料.doc

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Blueberry Extracts Protect Testis from Hypobaric Hypoxia Induced Oxidative Stress in Rats英文文献资料

HindawiPublishingCorporation OxidativeMedicineandCellularLongevity Volume2012,ArticleID975870,7pages doi:10.1155/2012/975870 ResearchArticle BlueberryExtractsProtectTestisfromHypobaricHypoxia InducedOxidativeStressinRats AndreaZepeda, 1 LuisG.Aguayo, 1 2 JorgeFuentealba, CarolinaFigueroa, 2 1 GloriaM.Calaf,3,4andJorgeFar′?as1 AlejandroAcevedo, PerlaSalgado, 1 1 2 DepartamentodeIngenier′?aQu′?mica,FacultaddeIngenier′?a,CienciasyAdministraci′on,UniversidaddeLaFrontera,Temuco,Chile NeuroactiveDrugsScreeningUnit,DepartamentodeFisiolog′?a,FacultaddeCienciasBiol′ogicas,UniversidaddeConcepci′on, Concepci′on,Chile 3 4 InstitutodeAltaInvestigaci′on,UniversidaddeTarapac′a,Arica,Chile CenterforRadiologicalResearch,ColumbiaUniversityMedicalCenter,NewYork,NY,USA CorrespondenceshouldbeaddressedtoJorgeFar′?as,jfarias@ufro.cl Received4June2012;Revised22August2012;Accepted26September2012 AcademicEditor:VincentPialoux Copyright?2012AndreaZepedaetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Exposuretohypobarichypoxiacausesoxidativedamagetomaleratreproductivefunction.Theaimofthisstudywastoevaluate theprotectivee?ectofablueberryextract(BB-4)intestisofratsexposedtohypobarichypoxia.Morphometricanalysis,cellular DNAfragmentation,glutathionereductase(GR),andsuperoxidedismutase(SOD)activitieswereevaluated.Ourresultsshowed thatsupplementationofBB-4reducedlipidperoxidation,decreasedapoptosis,andincreasedGRandSODactivitiesinrattestis underhypobarichypoxiaconditions(P 0.05).Therefore,thisstudydemonstratesthatblueberryextractsigni?cantlyreduced theharmfule?ectsofoxidativestresscausedbyhypobarichypoxiainrattestisbya?ectingglutathionereductaseandsuperoxide dismutaseactivities. 1.Introduction GRandenzymaticantioxidantmechanismsplayanessential roleinpreventingoxidativedamageincellsandtissues[10]. We have previously described that hypoba