Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis英文文献资料.docVIP

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Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis英文文献资料.doc

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Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis英文文献资料

HindawiPublishingCorporation NeurologyResearchInternational Volume2011,ArticleID205761,5pages doi:10.1155/2011/205761 ReviewArticle BriefReviewoftheRoleofGlycogenSynthaseKinase-3βin AmyotrophicLateralSclerosis Seong-HoKoh,WonkiBaek,andSeungH.Kim DepartmentofNeurology,CollegeofMedicineHanyangUniversity,no.17Haengdang-Dong,Seongdong-Gu, Seoul133-792,RepublicofKorea CorrespondenceshouldbeaddressedtoSeong-HoKoh,kimsh1@hanyang.ac.kr Received15November2010;Accepted23January2011 AcademicEditor:MamededeCarvalho Copyright?2011Seong-HoKohetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Glycogensynthasekinase-3β(GSK-3β)isknowntoa?ectadiverserangeofbiologicalfunctionscontrollinggeneexpression, cellulararchitecture,andapoptosis.GSK-3βhasrecentlybeenidenti?edasoneoftheimportantpathogenicmechanismsinmotor neuronaldeathrelatedtoamyotrophiclateralsclerosis(ALS).Therefore,thedevelopmentofmethodstocontrolGSK-3βcouldbe helpfulinpostponingthesymptomprogressionofALS.HerewediscusstheknownrolesofGSK-3βinmotorneuronalcelldeath inALSandthepossibilityofemployingGSK-3βmodulatorsasanewtherapeuticstrategy. 1.Introduction of Alzheimer’s disease (AD) and Parkinson’s disease (PD). The abnormal increase in the level and activity of GSK- 3β has beenassociated with neuronaldeath, paired helical ?lament tau formation, and neurite retraction in AD and inGSK-3βmediated6-hydroxydopamine-inducedneuronal deathininvitroandinvivomodelsofPD[12–14].Recently, ithasbeenreportedthattheroleofGSK-3βisimportantin thepathogenicmechanismsofALS.Forexample,GSK-3βis increasedinthethoracicspinalcordtissueofpatientswith sporadicALSandinmotoneuronstransfectedwithG93Aor theA4VmutanthSOD1gene[13,15]. Amyotrophic lateral sclerosis (ALS), characterized by pro- gressivemusclewastingandweakness,isaprogressive,fatal neurodegenerative disorder characterized by the preferen- tial loss of mot