Biophotonics Modalities for High-Resolution Imaging of Microcirculatory Tissue Beds Using Endogenous Contrast A Review on Present Scenario and Prospects英文文献资料.docVIP

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Biophotonics Modalities for High-Resolution Imaging of Microcirculatory Tissue Beds Using Endogenous Contrast A Review on Present Scenario and Prospects英文文献资料.doc

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Biophotonics Modalities for High-Resolution Imaging of Microcirculatory Tissue Beds Using Endogenous Contrast A Review on Present Scenario and Prospects英文文献资料

HindawiPublishingCorporation InternationalJournalofOptics Volume2011,ArticleID293684,20pages doi:10.1155/2011/293684 ReviewArticle BiophotonicsModalitiesforHigh-ResolutionImagingof MicrocirculatoryTissueBedsUsingEndogenousContrast: AReviewonPresentScenarioandProspects HrebeshM.Subhash BiophotonicsandFunctionalImagingLaboratory,DivisionofBiomedicalEngineering,SchoolofMedicine, OregonHealthandScienceUniversity,3303SWBondAvenue,Portland,OR97239,USA CorrespondenceshouldbeaddressedtoHrebeshM.Subhash,hrebeshms@ Received20October2010;Revised23February2011;Accepted10March2011 AcademicEditor:ArmandoNolascoPinto Copyright?2011HrebeshM.Subhash. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. The microcirculation is a complex system, and the visualization of microcirculation has great signi?cance in improving our understandingofpathophysiologicalprocessesinvariousdiseaseconditions,inbothclinicalandfundamentalstudies.Arange oftechniquesareavailableoremergingforinvestigatingdi?erentaspectofthemicrocirculationinanimalsandhumans.This paperreviewstherecentdevelopmentsinthe?eldofhigh-resolutionandhigh-sensitiveopticalimagingofmicrocirculatorytissue beds,emphasizingtechnologiesthatutilizetheendogenouscontrastmechanism.Opticalimagingtechniquessuchasintravital microscopy,Capillaroscopy,laserDopplerperfusionimaging,laserspeckleperfusionimaging,polarizationspectroscopy,photo- acoustictomography, andvarious implementationsof optical coherence tomographybased on Doppler and speckle contrast imagingarepresentedtogetherwiththeirprospectivesandchallenges. 1.Introduction in individual patients. Numerous imaging techniqueshave been proposed in the last few decades to image micro- circulation in medical research area, which vary widely by the type of microcirculatory information that they can provide and in their cost and availability.These me