Biosensing Technologies for Mycobacterium tuberculosis Detection Status and New Developments英文文献资料.docVIP

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Biosensing Technologies for Mycobacterium tuberculosis Detection Status and New Developments英文文献资料.doc

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Biosensing Technologies for Mycobacterium tuberculosis Detection Status and New Developments英文文献资料

HindawiPublishingCorporation ClinicalandDevelopmentalImmunology Volume2011,ArticleID193963,8pages doi:10.1155/2011/193963 ReviewArticle BiosensingTechnologiesforMycobacteriumtuberculosis Detection:StatusandNewDevelopments LixiaZhou,XiaoxiaoHe,DinggengHe,KeminWang,andDilanQin StateKeyLaboratoryofChemo/BiosensingandChemometrics,CollegeofBiologyandCollegeofChemistryandChemicalEngineering, HunanUniversityandKeyLaboratoryforBio-NanotechnologyandMoleculeEngineeringofHunanProvince, Changsha410082,China CorrespondenceshouldbeaddressedtoXiaoxiaoHe,xiaoxiaohe@andKeminWang,kmwang@ Received20October2010;Revised27December2010;Accepted10January2011 AcademicEditor:JamesTriccas Copyright?2011LixiaZhouetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. BiosensingtechnologiespromisetoimproveMycobacteriumtuberculosis(M.tuberculosis)detectionandmanagementinclinical diagnosis,foodanalysis,bioprocess,andenvironmentalmonitoring.Avarietyofportable,rapid,andsensitivebiosensorswith immediate“on-the-spot”interpretationhavebeendevelopedforM.tuberculosisdetectionbasedondi?erentbiologicalelements recognitionsystemsandbasicsignaltransducerprinciples.Here,wepresentasynopsisofcurrentdevelopmentsofbiosensing technologies for M. tuberculosis detection, which are classi?ed on the basis of basic signal transducer principles, including piezoelectric quartz crystal biosensors,electrochemical biosensors,andmagnetoelasticbiosensors.Special attentionispaidto themethodsforimprovingtheframeworkandanalyticalparametersofthebiosensors,includingsensitivityandanalysistimeas wellasautomationofanalysisprocedures.ChallengesandperspectivesofbiosensingtechnologiesdevelopmentforM.tuberculosis detectionarealsodiscussedinthe?nalpartofthispaper. 1.Introduction cell enrichment, but this process is time consuming and laborious, especially for the slow-growing bacteria like M. tubercu