Brucella abortus Strain RB51 Vaccine Immune Response after Calfhood Vaccination and Field Investigation in Italian Cattle Population英文文献资料.docVIP

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Brucella abortus Strain RB51 Vaccine Immune Response after Calfhood Vaccination and Field Investigation in Italian Cattle Population英文文献资料.doc

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Brucella abortus Strain RB51 Vaccine Immune Response after Calfhood Vaccination and Field Investigation in Italian Cattle Population英文文献资料

HindawiPublishingCorporation ClinicalandDevelopmentalImmunology Volume2008,ArticleID584624,6pages doi:10.1155/2008/584624 ResearchArticle BrucellaabortusStrainRB51Vaccine: ImmuneResponseafterCalfhoodVaccinationand FieldInvestigationinItalianCattlePopulation ManuelaTittarelli,1BarbaraBon?ni,1FabrizioDeMassis,1,2ArmandoGiovannini,1 MauroDiVentura,1DonatellaNannini,1andVincenzoCaporale1 1 2 IstitutoZoopro?latticoSperimentaledell’AbruzzoedelMolise“G.Caporale”,CampoBoario,64100Teramo,Italy DepartmentofAnimalhealthandWelfare(AHAW)Unit,EuropeanFoodSafetyAuthority(EFSA),43100Parma,Italy CorrespondenceshouldbeaddressedtoManuelaTittarelli,m.tittarelli@izs.it Received16July2007;Accepted8February2008 RecommendedbyYasunobuYoshikai ImmuneresponsetoBrucellaabortusstrainRB51vaccinewasmeasuredincattlevaccinatedatcalfhood.Afteranincreaseat day6post-vaccination(pv),theantibodylevelrecordedinthe10vaccinatedanimalsremainedconstantfortwomonths,and thenprogressivelydecreased.Allvaccinatedanimalsremainednegativefromday162pvtotheendofthestudy(day300pv). Onlyatdays13and14pvtheRB51-CFTshowed100%sensitivity(credibilityinterval(CI)76.2%–100%).Theresultsindicate that the possibility to use RB51-CFT for the identi?cation of cattle vaccinated at calfhood with RB51 is limited in time. A ?eld investigation was carried out on 26,975 sera collected on regional basis from the Italian cattle population. The study outcomesindicatethatincaseofRB51-CFTpositiveresultsobservedino?ciallyBrucellosis-free(OBF)areasand,inanycase, whenanillegaluseofRB51vaccineissuspected,theuseoftheRB51-CFTaloneisnotsu?cienttoidentifyallthevaccinated animals.Thedesignofamoresophisticateddiagnosticprotocolincludinganepidemiologicalinvestigation,theuseofRB51- CFT,andtheuseoftheskintestwithRB51asantigenisdeemedmoreappropriatefortheidenti?cationofRB51vaccinated animals. Copyright?2008ManuelaTittarellietal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distrib