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Calcium and Vitamin D Supplementation in Men英文文献资料
SAGE-HindawiAccesstoResearch
JournalofOsteoporosis
Volume2011,ArticleID875249,6pages
doi:10.4061/2011/875249
ResearchArticle
CalciumandVitaminDSupplementationinMen
EvelienGielen,1,2,3StevenBoonen,1,2,3DirkVanderschueren,3,4MiekeSinnesael,4
AnnemiekeVerstuyf, FrankClaessens,
4
5
KoenMilisen,1,6andSabineVerschueren
7
1
2
3
4
5
6
7
DivisionofGeriatricMedicine,LeuvenUniversityHospital,Herestraat49,3000Leuven,Belgium
GerontologyandGeriatricsSection,DepartmentofExperimentalMedicine,K.U.Leuven,3000Leuven,Belgium
LeuvenUniversityCentreforMetabolicBoneDiseases,3000Leuven,Belgium
ExperimentalMedicineandEndocrinology,DepartmentofExperimentalMedicine,K.U.Leuven,3000Leuven,Belgium
MolecularEndocrinologyLaboratory,DepartmentofMolecularCellBiology,K.U.Leuven,3000Leuven,Belgium
CentreforHealthServicesandNursingResearch,K.U.Leuven,3000Leuven,Belgium
ResearchCentreforMusculoskeletalRehabilitation,DepartmentofRehabilitationSciences,K.U.Leuven,3000Leuven,Belgium
CorrespondenceshouldbeaddressedtoStevenBoonen,steven.boonen@uzleuven.be
Received13April2011;Accepted4July2011
AcademicEditor:PawelSzulc
Copyright?2011EvelienGielenetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,
whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.
CalciumandvitaminDsupplementsreversesecondaryhyperparathyroidismandarewidelyprescribedtopreventosteoporotic
fractures, with proven antifracture e?cacy when targeted to individuals with documented insu?ciencies. Men who should
particularlybeconsideredforcalciumandvitaminDsupplementsincludeelderlyorinstitutionalizedindividuals,patientswith
documentedosteoporosisonantiresorptiveoranabolicmedication,andindividualsreceivingglucocorticoids.Bene?tsaremost
apparentwhenadailydoseof1000–1200mgcalciumiscomplementedwith800IUvitaminD.Complianceisthekeytooptimizing
clinicale?cacy.While(conventionallydosed)vitaminDhasnotbeenassociatedwithsafetyconcerns,recentmeta-analyticdata
haveprovidedevid
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