Calorie Restriction the Fountain of Youth英文文献资料.docVIP

Food and Nutrition Sciences, 2012, 3, 1522-1526 1 /10.4236/fns.2012.311198 Published Online November 2012 (http://www.SciRP.org/journal/fns) Calorie Restriction the Fountain of Youth Bashir Ahmed Dar , Manzoor Ahmed Dar , Sheeba Bashir 1* 2 3 1 Department of Medicine, Melaka Manipal Medical College, Melaka, Malaysia; har, Oman; drbashir123@, drmadar@, drsheeba98@ 2 Department of Surgery, Sohar Hospital Oman, So- 3 Department of Pathology, Acharya Shri Chander College of Medical Sciences Hospital (ASCOMS), Jammu, India. Email: * Received August 29 , 2012; revised September 29 , 2012; accepted October 7 , 2012 th th th ABSTRACT Calorie restriction (CR) is as close to a real fountain of youth as any known technique is. Caloric restriction known to extend the human lifespan by up to five years has quietly become accepted among leading researchers. Even scientists who are cautious about anti-aging hype say it works. The formula is simple: Eat less. It could add years to your life. In the context of health and longevity, I analyzed data documenting proofs which suggest that the caloric restriction ex- tends life span and retards age-related chronic diseases in a variety of species, including rats, mice, fish, flies, worms, and yeast as well as improve biomarkers of aging in humans. Research has shown that not only does it result in a longer lifespan, but it also lowers blood pressure, oxidative damage, cardiovascular disease, modifies insulin sensitivity, re- duces loss of central nervous system cells, strengthens the immune system, lowers cholesterol, diminishes the rate of heart disease, reduces muscle oxygen loss, improves muscle function, reduces free radical damage to body tissue and helps