Calotropis procera Latex Extract Affords Protection against Inflammation and Oxidative Stress in Freunds Complete Adjuvant-Induced Monoarthritis in Rats英文文献资料.docVIP

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Calotropis procera Latex Extract Affords Protection against Inflammation and Oxidative Stress in Freunds Complete Adjuvant-Induced Monoarthritis in Rats英文文献资料.doc

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Calotropis procera Latex Extract Affords Protection against Inflammation and Oxidative Stress in Freunds Complete Adjuvant-Induced Monoarthritis in Rats英文文献资料

HindawiPublishingCorporation MediatorsofIn?ammation Volume2007,ArticleID47523,7pages doi:10.1155/2007/47523 ResearchArticle CalotropisproceraLatexExtractAffordsProtection againstIn?ammationandOxidativeStressinFreund’s CompleteAdjuvant-InducedMonoarthritisinRats VijayL.KumarandSanjeevRoy DepartmentofPharmacology,AllIndiaInstituteofMedicalSciences,AnsariNagar,NewDelhi110029,India Received1December2006;Revised12February2007;Accepted12February2007 Inviewofthewell-establishedanti-in?ammatorypropertiesoflatexofCalotropisprocera(DL),thepresentstudywascarried outtoevaluatetheprotectivee?ectofitsmethanolextract(MeDL)againstin?ammationandoxidativestressinmonoarthritis inducedbyFreund’scompleteadjuvant(FCA)inrats.Intra-articularinjectionofFCAproducedin?ammationofthejointwith apeake?ectoccurringonday4whereamaximumincreaseinthelevelsofmyeloperoxidaseandin?ammatorymediatorslike PGE2,TNF-α,andnitricoxidewasobserved.Thiswasassociatedwithoxidativestresswithamarkedreductioninthelevelsof glutathione,catalase,superoxidedismutaseandglutathioneperoxidaseandanincreaseinthelipidperoxidationasindicatedbythe higherlevelsofthiobarbituricacidreactivesubstances(TBARSs).Subsequentlyonday28thehistologicalanalysisofthejointalso revealedarthriticchanges.DailytreatmentofratswithMeDL(50and500mg/kg)andstandardanti-in?ammatorydrugrofecoxib (20and100mg/kg),producedasigni?cantattenuationinthein?ammatoryresponseandamelioratedthearthriticchangesin thejoint.Theprotectiona?ordedbyMeDLandrofecoxibwasmorepronouncedthanthatofphenylbutazoneandwasassociated withnormalizationofthelevelsofin?ammatorymediatorsandbiochemicalparametersofoxidativestress.However,theoverall protectiona?ordedbyrofecoxibwasbetterthanthatofMeDL. Copyright?2007V.L.KumarandS.Roy.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. 1. INTRODUCTION (NO)inarthritishasbeenwellestablished.Thelevelsofthese in?amma