Caloric Restriction and the Nutrient-Sensing PGC-1 in Mitochondrial Homeostasis New Perspectives in Neurodegeneration英文文献资料.docVIP

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Caloric Restriction and the Nutrient-Sensing PGC-1 in Mitochondrial Homeostasis New Perspectives in Neurodegeneration英文文献资料.doc

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Caloric Restriction and the Nutrient-Sensing PGC-1 in Mitochondrial Homeostasis New Perspectives in Neurodegeneration英文文献资料

HindawiPublishingCorporation InternationalJournalofCellBiology Volume2012,ArticleID759583,11pages doi:10.1155/2012/759583 ReviewArticle CaloricRestrictionandtheNutrient-Sensing PGC-1αinMitochondrialHomeostasis: NewPerspectivesinNeurodegeneration DanieleLettieriBarbato, SaraBaldelli, BeatricePagliei, 1 1 1 KatiaAquilano, andMariaRosaCiriolo 1,2 1 1 2 DepartmentofBiology,UniversityofRome“TorVergata”,ViadellaRicercaScienti?ca1,00133Rome,Italy ResearchCenter,IRCCSSanRa?aeleLaPisana,ViadiValCannuta247,00166Rome,Italy CorrespondenceshouldbeaddressedtoKatiaAquilano,katia.aquilano@uniroma2.it andMariaRosaCiriolo,ciriolo@bio.uniroma2.it Received7May2012;Accepted8June2012 AcademicEditor:GiuseppeFilomeni Copyright?2012DanieleLettieriBarbatoetal. This is an open access article distributed under the Creative Commons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properlycited. Mitochondrialactivityprogressivelydeclinesduringageingandinmanyneurodegenerativediseases.Caloricrestriction(CR)has beensuggestedasadietaryinterventionthatisabletopostponethedetrimentalaspectsofagingasitamelioratesmitochondrial performance.Thise?ectispartiallyduetoincreasedmitochondrialbiogenesis.Thenutrient-sensingPGC-1αisatranscriptional coactivator that promotes the expression of mitochondrial genes and is induced by CR. It is believed that many of the mitochondrialandmetabolicbene?tsofCRareduetoincreasedPGC-1αactivity.TheincreaseofPGC-1αisalsopositivelylinked to neuroprotection and its decrement has been involved in the pathogenesis of many neurodegenerative diseases. This paper aimstosummarizethecurrentknowledgeabouttheroleofPGC-1αinneuronalhomeostasisandthebene?ciale?ectsofCRon mitochondrialbiogenesisandfunction.WealsodiscusshowPGC-1α-governedpathwayscouldbeusedastargetfornutritional interventiontopreventneurodegeneration. 1.Introduction throughgenetransfertothenucleus.Evenifmitochondria arecharacteri