Bone Mineral Density in Thalassemia Major Patients from Antalya, Turkey英文文献资料.docVIP

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Bone Mineral Density in Thalassemia Major Patients from Antalya, Turkey英文文献资料.doc

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Bone Mineral Density in Thalassemia Major Patients from Antalya, Turkey英文文献资料

HindawiPublishingCorporation InternationalJournalofEndocrinology Volume2012,ArticleID573298,4pages doi:10.1155/2012/573298 ClinicalStudy BoneMineralDensityinThalassemiaMajorPatientsfrom Antalya,Turkey IbrahimAslan, 1 DuranCanatan, NurgulOguz, 2 NihalBalta, GulizarKacar, CengaverDorak, 3 4 3 andRuyaCosan 3 AhmetOzsancak, 3 3 1 2 DepartmentofEndocrinologyandMetabolism,AntalyaEducationandResearchHospital,07100Antalya,Turkey HemoglobinopathyDiagnosisCenter,MediterraneanBloodDiseasesFoundationandThalassemiaFederationofTurkey, Antalya,Turkey 3 4 AntalyaStateHospital,07100Antalya,Turkey DepartmentofNuclearMedicine,AntalyaEducationandResearchHospital,07100Antalya,Turkey CorrespondenceshouldbeaddressedtoIbrahimAslan,iaslan@ Received28February2012;Revised23April2012;Accepted25April2012 AcademicEditor:MariaL.Dufau Copyright?2012IbrahimAslanetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Aim.Weassessedthebonemineraldensityandrelatedparametersinnineadults,thirty-eightpubertal,prepubertaltotallyforty- sevenpatientswiththalassemiamajorlivinginAntalya,Turkey.MaterialsandMethods.Wemeasuredheightandpubertalstaging in last ?ve years by six-month intervals. Average ferritin and hemoglobin concentrations were calculated for last three years. Thelevelsofhydroxyproline,calcium,phosphorus,andcreatinineweremeasuredin24hurine,andthoseofparathormone, IGF1,osteocalcine,alkalinephosphatase,calcium,ionizedcalcium,magnesium,phosphorus,creatine,bloodglucose,thyroid stimulatinghormone,alaninetransaminase,andaspartatetransaminaseweredeterminedinserum,andalsothebonemineral densitywasmeasured.Results.TheaverageL1–L4bonemassdensitywas27.1±10.1gcm?2;theaveragebonemineralcontentwas 0.65± 0.11g.ofthepatientswithaZ-scoreunder2.5.Amoderaterelationshipwasfoundbetweenthebonemassdensityageand height.Subjectsinlowpubertalstagingandshort