Both Acute and Chronic Placental Inflammation Are Overrepresented in Term Stillbirths A Case-Control Study英文文献资料.docVIP

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Both Acute and Chronic Placental Inflammation Are Overrepresented in Term Stillbirths A Case-Control Study英文文献资料.doc

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Both Acute and Chronic Placental Inflammation Are Overrepresented in Term Stillbirths A Case-Control Study英文文献资料

HindawiPublishingCorporation InfectiousDiseasesinObstetricsandGynecology Volume2012,ArticleID293867,8pages doi:10.1155/2012/293867 ClinicalStudy BothAcuteandChronicPlacentalIn?ammationAre OverrepresentedinTermStillbirths:ACase-ControlStudy IngelaHulth′enVarli, KarinPetersson, MariusKublickas, andNikosPapadogiannakis 1 2 2 3 1 2 3 DepartmentofObstetricsandGynecology,KarolinskaUniversityHospital,SolnaandKarolinskaInstitutet, 17176Stockholm,Sweden DepartmentofObstetricsandGynecology,KarolinskaUniversityHospital,HuddingeandKarolinskaInstitutet, 14186Stockholm,Sweden CentreforPerinatalPathologyandDepartmentofPathology,KarolinskaUniversityHospital, HuddingeandKarolinskaInstitutet,14186Stockholm,Sweden CorrespondenceshouldbeaddressedtoIngelaHulth′enVarli,ingela.hulthen-varli@karolinska.se Received23March2012;Accepted27June2012 AcademicEditor:HaroldWiesenfeld Copyright?2012IngelaHulth′enVarlietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Objective.Toelucidatedi?erencesinthefrequencyandseverityofacutechorioamnionitis(CAM)andchronicvillitisinplacentas fromstillbornscomparedwithlivebornsattermandtoevaluateotherriskfactorsandplacental?ndings.Design .Case-control study.Setting.AlldeliverywardsinmajorStockholmarea.PopulationorSample.Placentasfromstillborn/case(n = 126)and liveborn/control (n = 273) neonates were prospectively collected between 2002 and 2005. Methods. CAM was assessed on a three-gradescalebasedonthepresenceanddistributionofpolymorphonuclearleucocytesinthechorion/amnion.Thepresence ofvasculitisandfunisitiswasrecordedseparately.Chronicvillitiswasdiagnosedbythepresenceofmononuclearcellsinthe villousstroma.Relevantclinicaldatawerecollectedfromaspeciallyconstructed,web-baseddatabase.Thestatisticanalyseswere performedusingmultivariablelogisticregressi