Both and Lymphocytes Participate in the IFN-gammalcurlybrcurlyb Response to Filamentous Hemagglutinin from Bordetella pertussis in Infants, Children, and Adults英文文献资料.docVIP

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Both and Lymphocytes Participate in the IFN-gammalcurlybrcurlyb Response to Filamentous Hemagglutinin from Bordetella pertussis in Infants, Children, and Adults英文文献资料.doc

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Both and Lymphocytes Participate in the IFN-gammalcurlybrcurlyb Response to Filamentous Hemagglutinin from Bordetella pertussis in Infants, Children, and Adults英文文献资料

HindawiPublishingCorporation ClinicalandDevelopmentalImmunology Volume2012,ArticleID795958,9pages doi:10.1155/2012/795958 ResearchArticle BothCD4+andCD8+LymphocytesParticipatein theIFN-γResponsetoFilamentousHemagglutininfrom BordetellapertussisinInfants,Children,andAdults VioletteDirix, VirginieVerscheure, Franc?oiseVermeulen, IrisDeSchutter, 1 1 2 3 TessaGoetghebuer, 4CamilleLocht,5,6,7,8andFranc?oiseMascart 1,9 1 2 3 4 5 6 7 8 9 LaboratoryofVaccinologyandMucosalImmunity,Universit′eLibredeBruxelles(ULB),1070Brussels,Belgium PediatricDepartment,H?opitalErasme,Universit′eLibredeBruxelles(ULB),1070Brussels,Belgium PediatricDepartment,UZBrussel,VrijeUniversiteitBrussel(VUB),1090Brussels,Belgium PediatricDepartment,H?opitalSaint-Pierre,Universit′eLibredeBruxelles(ULB),1000Brussels,Belgium INSERMU1019,59000Lille,France CNRSUMR8204,59021Lille,France CenterforInfectionandImmunityofLille,InstitutPasteurdeLille,59019Lille,France UnivLilleNorddeFrance,59000Lille,France ImmunobiologyClinic,H?opitalErasme,Universit′eLibredeBruxelles(ULB),1070Brussels,Belgium CorrespondenceshouldbeaddressedtoFranc?oiseMascart,fmascart@ulb.ac.be Received20October2011;Revised23December2011;Accepted23December2011 AcademicEditor:K.Blaser Copyright?2012VioletteDirixetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. InfantCD4 responsesfocusedmainlyonviralandintracellularparasiteinfections.HereweinvestigatedCD8 pertussisinfectionininfants,children,andadultsandpertussisvaccinationininfants.Filamentoushemagglutinin-speci?cIFN- γ secretionbycirculatinglymphocytes wasblocked byanti-MHC-Ior-MHC-IIantibodies,suggestingthatCD4 andCD8 TlymphocytesareinvolvedinIFN-γproduction.Flowcytometryanalysescon?rmedthatbothcelltypessynthesizedantigen- speci?cIFN-γ,althoughCD4 lymphocyteswerethemajorsourceofthiscyto