Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1-Induced NF-kappalcurlybrcurlybB Activation in Canine Articular Chondrocytes英文文献资料.docVIP

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Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1-Induced NF-kappalcurlybrcurlybB Activation in Canine Articular Chondrocytes英文文献资料.doc

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Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1-Induced NF-kappalcurlybrcurlybB Activation in Canine Articular Chondrocytes英文文献资料

HindawiPublishingCorporation Evidence-BasedComplementaryandAlternativeMedicine Volume2012,ArticleID509383,16pages doi:10.1155/2012/509383 ResearchArticle BotanicalExtractsfromRosehip(Rosacanina), WillowBark(Salixalba),andNettleLeaf(Urticadioica) SuppressIL-1β-InducedNF-κBActivationin CanineArticularChondrocytes MehdiShakibaei, DavidAllaway, SimoneNebrich, andAliMobasheri 1 2 1 3 1 2 MusculoskeletalResearchGroup,InstituteofAnatomy,Ludwig-Maximilian-UniversityMunich,80336Munich,Germany NutritionandMetabolismResearchGroup,WALTHAMCentreforPetNutrition,WalthamontheWolds,MeltonMowbray, LeicestershireLE144RT,UK 3 MusculoskeletalResearchGroup,DivisionofVeterinaryMedicine,SchoolofVeterinaryMedicineandScience,FacultyofMedicineand HealthSciences,UniversityofNottingham,SuttonBoningtonCampus,SuttonBonington,LeicestershireLE125RD,UK CorrespondenceshouldbeaddressedtoAliMobasheri,ali.mobasheri@nottingham.ac.uk Received2July2011;Revised27October2011;Accepted10November2011 AcademicEditor:VirginiaS.Martino Copyright?2012MehdiShakibaeietal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Theaimofthisstudywastocharacterizetheanti-in?ammatorymodeofactionofbotanicalextractsfromrosehip(Rosacanina), willowbark(Salixalba),andnettleleaf(Urticadioica)inaninvitromodelofprimarycaninearticularchondrocytes.Methods.The biologicale?ectsofthebotanicalextractswerestudiedinchondrocytestreatedwithIL-1βforupto72h.Expressionofcollagen typeII,cartilage-speci?cproteoglycan(CSPG),β1-integrin,SOX-9,COX-2,andMMP-9andMMP-13wasexaminedbywestern blotting. Results. The botanical extracts suppressed IL-1β-induced NF-κB activation by inhibition of IκBα phosphorylation, IκBαdegradation,p65phosphorylation,andp65nucleartranslocation.TheseeventscorrelatedwithdownregulationofNF-κB targetsincludingCOX-2andMMPs.Theext